{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:27:57Z","timestamp":1773883677116,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T00:00:00Z","timestamp":1665187200000},"content-version":"vor","delay-in-days":280,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Lichen planopilaris (LPP) is a rare inflammatory disorder of the scalp that causes cicatricial alopecia. No therapeutic approach has been approved for this disease due to the rare frequency. Methotrexate and corticosteroid are commonly considered second\u2010 or third\u2010line therapy. The efficacy of a combination of methotrexate and corticosteroid has been reported in some dermatological and immunological diseases. However, the efficacy of this combination in LPP is not clear. Therefore, this study aimed to compare the impact of methotrexate alone and in combination with corticosteroid on LPP. <jats:italic>Materials and Methods<\/jats:italic>. This randomized clinical trial was performed on 28 patients who referred to the dermatology clinic affiliated with Isfahan University of Medical Sciences, Isfahan, Iran during February 2015\u2010December 2016, and 24 of them completed the trials. Fourteen patients received 15\u2009mg methotrexate per week alone and the other fourteen subjects received 200\u2009mg prednisolone plus 15\u2009mg methotrexate per week. The primary outcome was Lichen planopilaris activity index (LPPAI) score. Moreover, we evaluated photographic changes and symptoms during the study. <jats:italic>Results.<\/jats:italic> The mean of LPPAI in both groups decreased during the follow\u2010up with a similar pattern of LPPAI changes in both groups. No statistically significant difference was found between the two intervention groups regarding the LPPAI score. We found no difference in the symptoms and photographic assessments in methotrexate and combination therapy groups during follow\u2010up. In both groups, exclusively one adverse effect was reported. <jats:italic>Conclusions<\/jats:italic>. Our results showed that methotrexate therapy with and without corticosteroids had similar efficacy and safety.<\/jats:p>","DOI":"10.1155\/2022\/3792489","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T07:05:21Z","timestamp":1665299121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparative Efficacy Study Combination of Oral Methotrexate and Prednisolone versus Oral Methotrexate in Patients with Lichen Planopilaris"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0618-5512","authenticated-orcid":false,"given":"Farahnaz","family":"Fatemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9189-5780","authenticated-orcid":false,"given":"Farifteh","family":"Esfahanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-4378","authenticated-orcid":false,"given":"Ali","family":"Asilian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-2410","authenticated-orcid":false,"given":"Fatemeh","family":"Mohaghegh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5058-9050","authenticated-orcid":false,"given":"Mina","family":"Saber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,8]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"449","article-title":"Prevalence of hypercholesterolemia high LDL, and low HDL in Iran a systematic review and meta-analysis","volume":"43","author":"Akbartabar Toori M.","year":"2018","journal-title":"Iranian Journal of Medical Sciences"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.01.011"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01695.x"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2014.933165"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70078-v"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70290-v"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.280701.x"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.04.001"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.03.007"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.130409"},{"key":"e_1_2_10_11_2","first-page":"63","article-title":"Trichoscopy in lichen planopilaris an update","volume":"105","author":"Anna W.","year":"2018","journal-title":"Dermatol Rev\/Przegl Dermatol"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_81_16"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.05.018"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/s0190-9622(03)00873-9"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0738-081x(00)00132-2"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050466"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.12.038"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.12.006"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153923"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12141"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.054"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0122-z"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.5070\/d38z97b9jb"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12636"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2008.00472.x"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155502753600966"},{"key":"e_1_2_10_27_2","first-page":"787","article-title":"Comparative efficacy of methotrexate and mini pulse betamethasone in the treatment of lichen planus","volume":"22","author":"Hazra S. 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