{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:24Z","timestamp":1787017704877,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":327,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010731","name":"Faculty of Medicine, Chiang Mai University","doi-asserted-by":"publisher","award":["109\/2565"],"award-info":[{"award-number":["109\/2565"]}],"id":[{"id":"10.13039\/501100010731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010034","name":"Walailak University","doi-asserted-by":"publisher","award":["WU\u2212IRG\u221264\u2212004"],"award-info":[{"award-number":["WU\u2212IRG\u221264\u2212004"]}],"id":[{"id":"10.13039\/501100010034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioinorganic Chemistry and Applications"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Free heme in plasma acts as a prooxidant; thus, it is bound to hemopexin and eliminated by the liver. High iron content in the liver can support\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    growth and cause oxidative liver injury. Inversely, the withholding of excessive iron can inhibit this growth and protect the liver against malaria infection. This study examined the effects of a deferiprone\u2010resveratrol (DFP\u2010RVT) hybrid on malaria parasites and its relevant hepatoprotective properties. Mice were infected with\n                    <jats:italic>P. berghei<\/jats:italic>\n                    , gavage DFP\u2010RVT, deferiprone (DFP), and pyrimethamine (PYR) for 8 consecutive days. Blood and liver parameters were then evaluated. The presence of blood\u2010stage parasites was determined using the microscopic Giemsa staining method. Subsequently, plasma liver enzymes, heme, and concentrations of thiobarbituric acid\u2010reactive substances (TBARS) were determined. The liver tissue was examined pathologically and heme and TBARS concentrations were then quantified. The results indicate that the suppression potency against\n                    <jats:italic>P. berghei<\/jats:italic>\n                    growth occurred as follows: PYR\u2009&gt;\u2009DFP\u2010RVT hybrid\u2009&gt;\u2009DFP. Importantly, DFP\u2010RVT significantly improved RBC size, restored alanine aminotransferase and alkaline activities, and increased heme and TBARS concentrations. The compound also reduced the liver weight index, heme, and TBARS concentrations significantly when compared to mice that were untreated. Our findings support the contention that the hepatoprotective effect of DFP\u2010RVT is associated with parasite burden, iron depletion, and lipid peroxidation in the host.\n                  <\/jats:p>","DOI":"10.1155\/2022\/3869337","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T17:09:24Z","timestamp":1669309764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Deferiprone\u2212Resveratrol Hybrid, an Iron\u2010Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent in\n                    <i>Plasmodium berghei<\/i>\n                    \u2010Infected Mice"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-0105","authenticated-orcid":false,"given":"Hataichanok","family":"Chuljerm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supawadee","family":"Maneekesorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-9474","authenticated-orcid":false,"given":"Chuchard","family":"Punsawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-2139","authenticated-orcid":false,"given":"Voravuth","family":"Somsak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9891-8113","authenticated-orcid":false,"given":"Jetsada","family":"Ruangsuriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-8781","authenticated-orcid":false,"given":"Somdet","family":"Srichairatanakool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-7009","authenticated-orcid":false,"given":"Pimpisid","family":"Koonyosying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010767.pub2"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(13)60024-0"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m112.341255"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00881-2"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/15230860260220094"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00666"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201028"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1270"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci40258"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.768182"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf00717727"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(16)30269-9"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.2147\/idr.s279433"},{"key":"e_1_2_10_14_2","first-page":"239","article-title":"Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis","volume":"90","author":"Sturchler D.","year":"1987","journal-title":"Journal of Tropical Medicine & Hygiene"},{"key":"e_1_2_10_15_2","first-page":"30","article-title":"Liver injury in the course of malaria","volume":"51","author":"Goljan J.","year":"2000","journal-title":"International Maritime Health"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.1.375"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1988.39.236"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v87.11.4871.bloodjournal87114871"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1998.4371"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1179\/136485908x300832"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2015.1670"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0910-1"},{"key":"e_1_2_10_23_2","doi-asserted-by":"crossref","unstructured":"SmithH. J.andMeremikwuM. Iron Chelating Agents for Treating Malaria Cochrane Database Syst Rev 2 CD001474 https:\/\/doi.org\/10.1002\/14651858.CD001474.","DOI":"10.1002\/14651858.CD001474"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.09.019"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26134074"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology10090911"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.017"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407705-8.00001-X"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037171"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0162-0134(92)84072-u"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7487"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v84.3.910.910"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.150227"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-018697"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2509-9"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2014.1.404"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0950-3536(11)80022-3"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.4.e48"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq041"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21933"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1086\/431152"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/796182"},{"key":"e_1_2_10_43_2","first-page":"119","article-title":"Plasmodium berghei induces apoptotic changes in splenic and peripheral blood cells","volume":"28","author":"Kapoor G.","year":"2011","journal-title":"Tropical Biomedicine"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2004.09.006"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.09.018"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1159\/000494604"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0103-507x2011000300015"},{"key":"e_1_2_10_48_2","first-page":"1359","article-title":"A quantitative ultrastructural study of the liver and the spleen in fatal falciparum malaria","volume":"36","author":"Prommano O.","year":"2005","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2008.01078.x"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2402-6"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008599"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.03.004"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1179\/136485909x385054"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1986.tb00304.x"}],"container-title":["Bioinorganic Chemistry and Applications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bca\/2022\/3869337.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bca\/2022\/3869337.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/3869337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T10:37:38Z","timestamp":1721299058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/3869337"}},"subtitle":[],"editor":[{"given":"Demetrio","family":"Milea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/3869337"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3869337","archive":["Portico"],"relation":{},"ISSN":["1565-3633","1687-479X"],"issn-type":[{"value":"1565-3633","type":"print"},{"value":"1687-479X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3869337"}}