{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:24:56Z","timestamp":1740173096212,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinical Research Center of Thyroid Diseases of Shanghai Health Medical College","award":["20MC20200002","ZK2019C09","81873636","PWZy2020-12"],"award-info":[{"award-number":["20MC20200002","ZK2019C09","81873636","PWZy2020-12"]}]},{"name":"Shanghai Medical Key Specialty","award":["20MC20200002","ZK2019C09","81873636","PWZy2020-12"],"award-info":[{"award-number":["20MC20200002","ZK2019C09","81873636","PWZy2020-12"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20MC20200002","ZK2019C09","81873636","PWZy2020-12"],"award-info":[{"award-number":["20MC20200002","ZK2019C09","81873636","PWZy2020-12"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pudong New Area Health Commission Key Subspecialty","award":["20MC20200002","ZK2019C09","81873636","PWZy2020-12"],"award-info":[{"award-number":["20MC20200002","ZK2019C09","81873636","PWZy2020-12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,4,26]]},"abstract":"<jats:p>Objective. To explore the association of ATG5 gene polymorphisms with autoimmune thyroid diseases (AITDs) including Hashimoto\u2019s thyroiditis (HT) and Graves\u2019 illness (GD) as well as their clinical features. Methods. rs6568431, rs548234, and rs6937876 were selected to investigate the correlation of single-nucleotide polymorphisms of ATG5 gene with AITDs. Their frequencies in 824 AITD patients, including 271 HT patients and 553 GD patients, and 764 healthy controls were tested using both ligase detection reaction and multiplex polymerase chain reaction. Results. Allele A frequency of rs6568431 in AITDs patients (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.016<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>OR<\/c:mtext>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>1.201<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, 95% <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>CI<\/e:mtext>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>1.034<\/e:mn>\n                        <e:mo>\u2212<\/e:mo>\n                        <e:mn>1.394<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and allele G frequency of rs6937876 in AITDs patients (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.009<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mtext>OR<\/i:mtext>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>1.223<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, 95% <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mtext>CI<\/k:mtext>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>1.052<\/k:mn>\n                        <k:mo>\u2212<\/k:mo>\n                        <k:mn>1.422<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>) and in GD patients (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.009<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mtext>OR<\/o:mtext>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>1.247<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>, 95% <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mtext>CI<\/q:mtext>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>1.056<\/q:mn>\n                        <q:mo>\u2212<\/q:mo>\n                        <q:mn>1.473<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>) were significantly higher than those in the healthy controls. The frequency of G allele (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>p<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>5.42<\/s:mn>\n                        <s:mtext>E<\/s:mtext>\n                        <s:mo>\u2212<\/s:mo>\n                        <s:mn>18<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mtext>OR<\/u:mtext>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>0.242<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>, 95% <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mtext>CI<\/w:mtext>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>0.173<\/w:mn>\n                        <w:mo>\u2212<\/w:mo>\n                        <w:mn>0.339<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>) of rs6937876 was significantly higher in GD patients with ophthalmopathy. However, no relationship was found between family history, age onset, and the three SNPs. Conclusion. The study is the first to reveal the association between AITDs and ATG5 polymorphisms, and ATG5 gene is considered as a predisposing gene to AITDs, especially GDs.<\/jats:p>","DOI":"10.1155\/2022\/3881417","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T20:50:10Z","timestamp":1651006210000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Polymorphisms of ATG5 Gene Are Associated with Autoimmune Thyroid Diseases, Especially Thyroid Eye Disease"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-1580","authenticated-orcid":true,"given":"Wen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, No. 1500 Zhouyuan Road, Pudong District, Shanghai, 201318, China"},{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai, 201508, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0932-0495","authenticated-orcid":true,"given":"Zheng-yao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Shanghai Songjiang District Central Hospital, No. 746 Middle Zhongshan Road, Shanghai, 201600, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6779-4576","authenticated-orcid":true,"given":"Rong-hua","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, No. 1500 Zhouyuan Road, Pudong District, Shanghai, 201318, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5844-7479","authenticated-orcid":true,"given":"Shuang-tao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai, 201508, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7473-1952","authenticated-orcid":true,"given":"Liang-feng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, Jinshan District, Shanghai, 201508, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1700-4695","authenticated-orcid":true,"given":"Jin-an","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, No. 1500 Zhouyuan Road, Pudong District, Shanghai, 201318, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0015"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01894.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20991"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02334"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5.2.7348"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.140111"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/ng.479"},{"issue":"18","key":"8","first-page":"2863","article-title":"Rs548234 polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis in Caucasians is not associated with rheumatoid arthritis in Chinese Han population","volume":"124","author":"X. 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