{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:59:45Z","timestamp":1765382385245,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2022,10,31]]},"abstract":"<jats:p>Background. We compared the clinico-radio-pathological characteristics of breast cancer detected through mammogram (MMG) and ultrasound (USG) and discuss the implication of the choice of imaging as the future direction of our recently launched local screening program. Methods. Retrospective study of 14613 Hong Kong Chinese female patients with histologically confirmed breast cancer registered in the Hong Kong Breast Cancer Registry between January 2006 and February 2020. Patients were classified into four groups based on the mode of breast cancer detection (detectable by both mammogram and ultrasound (MMG+\/USG+), mammogram only (MMG+\/USG\u2212), ultrasound only (MMG\u2212\/USG+), or not detectable by either (MMG\u2212\/USG\u2212). Characteristics of breast cancer detected were compared, including patient demographics, breast density on MMG, mode of presentation, tumour size, histological type, and staging. Types of mammographic abnormalities were also evaluated for MMG+ subgroups. Results. 85% of the cancers were detectable by MMG, while USG detected an additional 9%. MMG+\/USG+ cancers were larger, more advanced in stage, often of symptomatic presentation, and commonly manifested as mammographic mass. MMG+\/USG\u2212 cancers were more likely of asymptomatic presentation, manifested as microcalcifications, and of earlier stage and to be ductal carcinoma in situ. MMG\u2212\/USG+ cancers were more likely seen in young patients and those with denser breasts and more likely of symptomatic presentation. MMG\u2212\/USG\u2212 cancers were often smaller and found in denser breasts. Conclusion. Mammogram has a good detection rate of cancers in our local population. It has superiority in detecting early cancers by detecting microcalcifications. Our current study agrees that ultrasound is one of the key adjunct tools of breast cancer detection.<\/jats:p>","DOI":"10.1155\/2022\/3882936","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T22:20:06Z","timestamp":1667254806000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Characteristics of Breast Cancer Detected through Different Imaging Modalities in a Large Cohort of Hong Kong Chinese Women: Implication of Imaging Choice on Upcoming Local Screening Program"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3938-4131","authenticated-orcid":true,"given":"Yik Shuen","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Imaging & Interventional Radiology, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong SAR, China"},{"name":"Department of Imaging & Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-952X","authenticated-orcid":true,"given":"Wai Ka","family":"Hung","sequence":"additional","affiliation":[{"name":"Hong Kong Breast Cancer Foundation, 22\/F, Jupiter Tower, 9 Jupiter Street, North Point, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-7265","authenticated-orcid":true,"given":"Lok Wa","family":"Yuen","sequence":"additional","affiliation":[{"name":"Hong Kong Breast Cancer Foundation, 22\/F, Jupiter Tower, 9 Jupiter Street, North Point, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2095-7910","authenticated-orcid":true,"given":"Ho Yan Yolanda","family":"Chan","sequence":"additional","affiliation":[{"name":"Breast Health Clinic, CUHK Medical Centre, 9 Chak Cheung Street, Shatin, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-4132","authenticated-orcid":true,"given":"Chiu Wing Winnie","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Imaging & Interventional Radiology, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong SAR, China"},{"name":"Department of Imaging & Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-7779","authenticated-orcid":true,"given":"Polly Suk Yee","family":"Cheung","sequence":"additional","affiliation":[{"name":"Hong Kong Breast Cancer Foundation, 22\/F, Jupiter Tower, 9 Jupiter Street, North Point, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"article-title":"Breast cancer","year":"2021","author":"World Health Organization","key":"1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1787\/26b007cd-en"},{"volume-title":"Global Cancer Observatory: Cancer Today","year":"2020","author":"J. 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World health organization","year":"2014","author":"World Health Organization","key":"5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0447"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-021-00295-9"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.13.1081"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s1047-2797(00)00225-8"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-4054-y"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.06.048"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06992-1"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.7326\/m15-0969"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.207.1.9530316"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-007-0024-x"},{"volume-title":"Supplemental Screening for Breast Cancer in Women with Dense Breasts: A Systematic Review for the U.S. Preventive Service Task Force","year":"2016","author":"J. 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