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Although the oral drug metformin (MH) is widely used to reduce hyperglycemia, it is associated with adverse effects. Therefore, there is an urgent need to search for safe and natural foods that do not cause adverse effects as alternatives to commercial drugs. In this study, the active substances from <jats:italic>Spirulina platensis<\/jats:italic>, <jats:italic>Grifola frondosa<\/jats:italic>, <jats:italic>Panax ginseng<\/jats:italic>, and chromium\u2010rich yeast were used to obtain <jats:italic>Spirulina<\/jats:italic> functional formulations (SFFs), and its therapeutic effects on mice with glycolipid metabolism disorder (GLD) were investigated. Results showed that SFFs not only improved glycolipid metabolism and reduced inflammation in mice with GLD but also showed good regenerative effects on the liver, jejunum, and cecum tissues. Moreover, SFFs could inhibit the growth of harmful microbes in the intestine and promote the proliferation of beneficial bacteria, thereby promoting the production of short\u2010chain fatty acids and further regulating GLD. Additionally, SFFs significantly increased the expression of INS, INSR, IRS\u20101, PI3K, AKT\u20101, and GLUT\u20104 genes and significantly decreased that of GSK\u20103<jats:italic>\u03b2<\/jats:italic> in the INS\/PI3K\/GLUT\u20104 signaling pathway. Therefore, the findings of this study suggest that SFFs can be further developed as a new class of therapeutic agents against GLD.<\/jats:p>","DOI":"10.1155\/2022\/3910116","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T22:35:10Z","timestamp":1657751710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ameliorating Effect on Glycolipid Metabolism of <i>Spirulina<\/i> Functional Formulation Combination from Traditional Chinese 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