{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:30:11Z","timestamp":1787243411161,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":185,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017955","name":"Fujian Provincial Health and Family Planning Commission","doi-asserted-by":"publisher","award":["2017-1-34"],"award-info":[{"award-number":["2017-1-34"]}],"id":[{"id":"10.13039\/100017955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>The aim is to study lung cancer with Lambert\u2010Eaton myasthenic syndrome (LEMS) with clinical and electrical characteristics of physiology and prognosis. Fourteen LEMS patients with lung cancer were studied retrospectively. The data including demographics, clinical presentation, treatments, and prognosis from the medical records were analyzed. Lung cancer coexisting with LEMS is more common in men (10\/14). The median age was 67.1 years. Eleven (78.6%) patients experienced gradual onset of disease. Most patients presented nervous system lesions prior to occult tumors. The most common symptoms reported were proximal muscle weakness (92.9%), decreased or absent tendon reflexes (50%), and autonomic dysfunction (71.4%). All the patients showed reduction in action potential amplitude after repetitive peripheral never stimulation at low frequency and increased amplitude at high frequency. LEMS usually occurs prior to lung cancer with complicated and various clinical manifestations in our centers. We should improve awareness and knowledge of such disease to shorten the diagnostic delay and lead to few misdiagnoses.<\/jats:p>","DOI":"10.1155\/2022\/3912376","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T14:36:02Z","timestamp":1657031762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lambert\u2010Eaton Myasthenic Syndrome in Lung Cancer"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yongbin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanguo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-9675","authenticated-orcid":false,"given":"Xiaojuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9821-8774","authenticated-orcid":false,"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(11)70245-9"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.01.008"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(53)91358-0"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8541-9"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12218"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000130254.27019.14"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-015-0034-0"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25520"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-6-281"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/2632010x211051741"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03220.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.17.5133"},{"key":"e_1_2_9_13_2","first-page":"871","article-title":"Small-cell lung cancer presenting with Lambert-Eaton myasthenic syndrome and respiratory failure","volume":"101","author":"Jiang J. 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