{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:34:36Z","timestamp":1777030476462,"version":"3.51.4"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hainan Province Clinical Medical Center and Applied Basic Research Program (Natural Science Field) High-level Talent Project","award":["2019RC386"],"award-info":[{"award-number":["2019RC386"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2022,10,6]]},"abstract":"<jats:p>Small extracellular vesicles (sEVs) secreted by mesenchymal stem cells (MSCs) have shown great therapeutic potential in cerebral ischemia-reperfusion injury (CIRI). In this study, we firstly performed a systematic review to evaluate the efficacy of MSCs-derived sEV for experimental cerebral ischemia\/reperfusion injury. 24 studies were identified by searching 8 databases from January 2012 to August 2022. The methodological quality was assessed by using the SYRCLE \u2018s risk of bias tool for animal studies. All the data were analyzed using RevMan 5.3 software. As a result, the score of study quality ranged from 3 to 9 in a total of ten points. Meta-analyses showed that MSCs-derived sEVs could effectively alleviate neurological impairment scores, reduced the volume of cerebral infarction and brain water content, and attenuated neuronal apoptosis. Additionally, the possible mechanisms of MSCs-derived sEVs for attenuating neuronal apoptosis were inhibiting microglia-mediated neuroinflammation. Thus, MSCs-derived sEVs might be regarded as a novel insight for cerebral ischemic stroke. However, further mechanistic studies, therapeutic safety, and clinical trials are required. Systematic review registration. PROSPERO CRD42022312227.<\/jats:p>","DOI":"10.1155\/2022\/3933252","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T23:05:16Z","timestamp":1665097516000},"page":"1-15","source":"Crossref","is-referenced-by-count":11,"title":["Inhibition of Cerebral Ischemia\/Reperfusion Injury by MSCs-Derived Small Extracellular Vesicles in Rodent Models: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7119-6969","authenticated-orcid":true,"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoying","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4824-9457","authenticated-orcid":true,"given":"Guoshuai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5575-2723","authenticated-orcid":true,"given":"Dan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018778713"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2016.06.008"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S210035"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111303"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-019-0083-6"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146432"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-02007-4"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120212"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8883636"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2093940"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020510"},{"key":"12","first-page":"9261","article-title":"Bone marrow mesenchymal stem cells effects on retinal ischemia-reperfusion injury after subretinal transplantation","volume":"12","author":"Y. S. Zhao","year":"2008","journal-title":"Journal of Clinical Rehabilitative Tissue Engineering Research"},{"key":"13","article-title":"Intravenous injection of adult human bone marrow mesenchymal stromal cells attenuates spinal cord ischemia reperfusion injury in a mouse aortic arch cross clamping model","volume":"138","author":"Y. Fujita","year":"2018","journal-title":"Circulation"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26726"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0036-9"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.125"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0991-5"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2010.06.006"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00294"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2021.101678"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801821R"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2019.0194"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2021.10.017"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.01.022"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.09.002"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.08.021"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.33594\/000000090"},{"issue":"17","key":"28","article-title":"Effect of exosomes derived from adipose-derived mesenchymal stem cells on neuron apoptosis and inflammatory cytokines in a rat model of cerebral ischemia reperfusion","volume":"41","author":"H. Hao","year":"2019","journal-title":"Journal of Army Medical University"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-1725-8"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-02998-0"},{"key":"31","article-title":"Effects of exosomes derived from H-BDNF-MSCs on neurons apoptosis in rats cerebral ischemia-reperfusion injury","author":"Z. Pan","year":"2020","journal-title":"University of South China"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2020.1743912"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.569977"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8814239"},{"key":"35","article-title":"Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1\/M2 phenotypes","volume":"341, article 113700","author":"X. Liu","year":"2021","journal-title":"Experimental Neurology"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-021-00324-0"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202466"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.568304"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12902"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S248892"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2021.1938829"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.2012402"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01761-0"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03179-9"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-022-00997-4"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03083-9"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118403"},{"key":"48","volume-title":"The restoration effect of the exosomes derived from high-expression BDNF MSCs in MCAO rats","author":"F. An","year":"2019"},{"key":"49","volume-title":"Effects of bone marrow mesenchymal stem cells-derived miR-30c-5p on polarization of microglia in cerebral ischemia reperfusion and its mechanisms","author":"H. Yu","year":"2020"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.35369"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-43"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201600057"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.23736\/S0390-5616.17.03989-3"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.09.032"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00423.2016"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.07.067"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04559-y"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0439"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.08.048"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11570"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6169-0"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.04.037"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14926"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.01.005"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.207"}],"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2022\/3933252.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2022\/3933252.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2022\/3933252.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T23:05:28Z","timestamp":1665097528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/np\/2022\/3933252\/"}},"subtitle":[],"editor":[{"given":"Gabriela","family":"Delevati Colpo","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":66,"alternative-id":["3933252","3933252"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3933252","relation":{},"ISSN":["1687-5443","2090-5904"],"issn-type":[{"value":"1687-5443","type":"electronic"},{"value":"2090-5904","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,6]]}}}