{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:24:39Z","timestamp":1782800679269,"version":"3.54.5"},"reference-count":142,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":143,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973801"],"award-info":[{"award-number":["81973801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Diabetic cardiomyopathy (DCM) is the main factor responsible for poor prognosis and survival in patients with diabetes. The highly complex pathogenesis of DCM involves multiple signaling pathways, including nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) signaling pathway, adenosine monophosphate\u2010activated protein kinase (AMPK) signaling pathway, phosphatidylinositol 3\u2010kinase\u2010protein kinase B (Akt) signaling pathway, mitogen\u2010activated protein kinase (MAPK) signaling pathway, and transforming growth factor\u2010<jats:italic>\u03b2<\/jats:italic> (TGF\u2010<jats:italic>\u03b2<\/jats:italic>) signaling pathway. Nuclear factor erythroid\u20102\u2010related factor 2 (Nrf2) seems essential to the amelioration of the progression of DCM, not only through counterbalancing oxidative stress, but also through interacting with other signaling pathways to combat inflammation, the disorder in energy homeostasis and insulin signaling, and fibrosis. It has been evidenced that Chinese herbal monomers could attenuate DCM through the crosstalk of Nrf2 with other signaling pathways. This article has summarized the pathogenesis of DCM (especially in oxidative stress), the beneficial effects of ameliorating DCM via the Nrf2 signaling pathway and its crosstalk, and examples of Chinese herbal monomers. It will facilitate pharmacological research and development to promote the utilization of traditional Chinese medicine in DCM.<\/jats:p>","DOI":"10.1155\/2022\/3959390","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T18:05:09Z","timestamp":1653415509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-939X","authenticated-orcid":false,"given":"Yiwei","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-4355","authenticated-orcid":false,"given":"Xin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangning","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-2979","authenticated-orcid":false,"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.658948"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/CHEST.115.3.867"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.METABOL.2021.154910"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1479164109338774"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/DOM.14388"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/DOM.14490"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3206542"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/PHYSIOLGENOMICS.00041.2017"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBAMCR.2018.02.010"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.FREERADBIOMED.2015.06.006"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00125-017-4390-4"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/NRENDO.2015.216"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.223545"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2021.750382"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5512322"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63176-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/S10495-009-0419-6"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160503C"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00125-014-3171-6"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/10520299809140509"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.YJMCC.2015.12.011"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11951"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BEEM.2009.03.002"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1113\/JPHYSIOL.2007.135871"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.00424.2012"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBADIS.2017.07.025"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-11-0236"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS9061558"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.REDOX.2013.07.006"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2019.109368"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.YJMCC.2020.09.003"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.CBPB.2005.04.022"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHARMTHERA.2013.07.004"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/S41401-018-0042-6"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.563213"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPENDO.00497.2011"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715769900300881"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568009617666171002144228"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.FREERADBIOMED.2009.07.035"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/S10741-018-9749-1"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.4093\/DMJ.2014.38.5.337"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2018.11.064"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7845681"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2021.112412"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/JCMM.14870"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2150218"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211002885"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X15500664"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/S12012-017-9430-2"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7239123"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0B013E328328D0A4"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/CR.2011.13"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/NRI2423"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(09)70111-2"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/SJ.ONC.1209954"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/NI.1606"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.YJMCC.2008.06.009"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.M507553200"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1124\/PR.114.010090"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.4049\/JIMMUNOL.173.6.3589"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE10759"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1096\/FJ.201701536R"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1089\/JIR.2008.0027"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2017.00798"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.FREERADBIOMED.2011.06.012"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/MP100199M"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBADIS.2016.11.005"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2017.05.148"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/S12020-018-1525-4"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9086747"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.CBI.2019.108754"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBRC.2006.10.102"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211045948"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2017.02.052"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1089\/ARS.2005.7.889"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHYMED.2018.11.034"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1089\/ARS.2015.6615"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLCEL.2009.07.025"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1089\/ARS.2010.3534"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.1242\/JCS.01540"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1152\/AJPHEART.00210.2014"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.TEM.2014.11.001"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1074\/JBC.270.29.17513"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1111\/BPH.12475"},{"key":"e_1_2_6_86_2","doi-asserted-by":"publisher","DOI":"10.1152\/JAPPLPHYSIOL.00071.2002"},{"key":"e_1_2_6_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/NRM.2017.95"},{"key":"e_1_2_6_88_2","doi-asserted-by":"publisher","DOI":"10.3892\/OL.2012.931"},{"key":"e_1_2_6_89_2","doi-asserted-by":"publisher","DOI":"10.1136\/HRT.2005.071233"},{"key":"e_1_2_6_90_2","doi-asserted-by":"publisher","DOI":"10.1046\/J.1365-2362.2003.01222.X"},{"key":"e_1_2_6_91_2","doi-asserted-by":"publisher","DOI":"10.1085\/JGP.201812183"},{"key":"e_1_2_6_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHYMED.2018.11.025"},{"key":"e_1_2_6_93_2","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2021.791643"},{"key":"e_1_2_6_94_2","doi-asserted-by":"publisher","DOI":"10.1089\/ARS.2012.5116"},{"key":"e_1_2_6_95_2","doi-asserted-by":"publisher","DOI":"10.1007\/S10557-018-6780-3"},{"key":"e_1_2_6_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBRC.2017.06.076"},{"key":"e_1_2_6_97_2","doi-asserted-by":"publisher","DOI":"10.26402\/JPP.2020.6.12"},{"key":"e_1_2_6_98_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00118-16"},{"key":"e_1_2_6_99_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.249532"},{"key":"e_1_2_6_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.CHEMPHYSLIP.2021.105138"},{"key":"e_1_2_6_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/S41467-019-10386-8"},{"key":"e_1_2_6_102_2","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21010265"},{"key":"e_1_2_6_103_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.007054"},{"key":"e_1_2_6_104_2","doi-asserted-by":"publisher","DOI":"10.7150\/IJBS.40923"},{"key":"e_1_2_6_105_2","doi-asserted-by":"publisher","DOI":"10.1177\/2040622320901990"},{"key":"e_1_2_6_106_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2563508"},{"key":"e_1_2_6_107_2","doi-asserted-by":"publisher","DOI":"10.1186\/S13287-019-1544-Y"},{"key":"e_1_2_6_108_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9265016"},{"key":"e_1_2_6_109_2","doi-asserted-by":"publisher","DOI":"10.2337\/DB10-1164"},{"key":"e_1_2_6_110_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4602715"},{"key":"e_1_2_6_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.ENVPOL.2019.113812"},{"key":"e_1_2_6_112_2","doi-asserted-by":"publisher","DOI":"10.1111\/JCMM.14413"},{"key":"e_1_2_6_113_2","doi-asserted-by":"publisher","DOI":"10.21037\/APM-19-516"},{"key":"e_1_2_6_114_2","doi-asserted-by":"publisher","DOI":"10.1002\/JBT.22548"},{"key":"e_1_2_6_115_2","doi-asserted-by":"publisher","DOI":"10.3390\/ANTIOX8030069"},{"key":"e_1_2_6_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/SREP41491"},{"key":"e_1_2_6_117_2","doi-asserted-by":"publisher","DOI":"10.1038\/SREP44239"},{"key":"e_1_2_6_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHYMED.2020.153319"},{"key":"e_1_2_6_119_2","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2018.00782"},{"key":"e_1_2_6_120_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00210-019-01716-0"},{"key":"e_1_2_6_121_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6304058"},{"key":"e_1_2_6_122_2","doi-asserted-by":"publisher","DOI":"10.1210\/ER.2007-0015"},{"key":"e_1_2_6_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.REDOX.2018.07.008"},{"key":"e_1_2_6_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2021.111361"},{"key":"e_1_2_6_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHYMED.2020.153406"},{"key":"e_1_2_6_126_2","doi-asserted-by":"publisher","DOI":"10.1096\/FJ.03-1273REV"},{"key":"e_1_2_6_127_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00395-008-0715-2"},{"key":"e_1_2_6_128_2","doi-asserted-by":"publisher","DOI":"10.1152\/PHYSREV.00012.2007"},{"key":"e_1_2_6_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.REDOX.2015.08.015"},{"key":"e_1_2_6_130_2","first-page":"215","article-title":"Cytokines and human fibrosis","volume":"1","author":"LeRoy E. C.","year":"1990","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_6_131_2","doi-asserted-by":"publisher","DOI":"10.1007\/S00109-007-0249-3"},{"key":"e_1_2_6_132_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000187457.24338.3D"},{"key":"e_1_2_6_133_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8370593"},{"key":"e_1_2_6_134_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3732718"},{"key":"e_1_2_6_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBADIS.2016.11.006"},{"key":"e_1_2_6_136_2","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2018.00774"},{"key":"e_1_2_6_137_2","doi-asserted-by":"publisher","DOI":"10.1038\/S41419-020-2365-8"},{"key":"e_1_2_6_138_2","doi-asserted-by":"publisher","DOI":"10.26402\/JPP.2021.3.04"},{"key":"e_1_2_6_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.FREERADBIOMED.2019.04.033"},{"key":"e_1_2_6_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JEP.2007.05.032"},{"key":"e_1_2_6_141_2","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0093265"},{"key":"e_1_2_6_142_2","doi-asserted-by":"publisher","DOI":"10.1002\/MNFR.202000231"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/3959390.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/3959390.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/3959390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:43:20Z","timestamp":1748911400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/3959390"}},"subtitle":[],"editor":[{"given":"Yuli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":142,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/3959390"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3959390","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3959390"}}