{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:04:48Z","timestamp":1792037088298,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2022,1,29]]},"abstract":"<jats:p>Introduction. Due to the early diagnosis of primary hyperparathyroidism the musculoskeletal manifestations of this disease are becoming less frequent. When this disease manifests secondary to a giant adenoma, it presents with more aggressive symptoms and can have important repercussions such as the hungry bone syndrome after parathyroidectomy. There are few reported cases of hyperparathyroidism secondary to a giant adenoma in the literature, as the presence of a brown tumor is often misinterpreted as a metastatic lesion from an unknown primary tumor. Methods. We describe a case and performed a literature review to identify all case reports. A literature search was carried out on PubMed\/MEDLINE and EMBASE bibliographic databases. All available studies from May 2009 to May 2021 were included. Data were tabulated, and outcomes were cumulatively analyzed. Results. Twenty-four cases of primary hyperparathyroidism due to giant adenoma have been described; the majority were women, with a mean age of 52\u2009years. They presented with heterogeneous symptoms such as palpable nodules (45%), bone pain (33%), brown tumor (12.5%), asymptomatic (12.5%), metabolic profile with a mean calcemia of 13.8\u2009mg\/dL, PTH 1109\u2009ng\/L, and mean tumor weight of 47.24\u2009g. Conclusion. Primary hyperparathyroidism due to giant adenoma increases the risk of developing potentially serious postoperative complications such as hungry bone syndrome. This implies the need of implementing preventive measures comprising administration of intravenous zoledronic acid and early supplementation of oral calcium to prevent complications after resection.<\/jats:p>","DOI":"10.1155\/2022\/3969542","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T14:50:09Z","timestamp":1643467809000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Giant Parathyroid Adenoma-Associated Fracture, Not All Lytic Bone Lesions are Cancer: A Case-Based Review"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-3866","authenticated-orcid":true,"given":"Jose C.","family":"Alvarez-Payares","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Universidad de Antioquia, Hospital Universitario, San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel E.","family":"Ribero","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Universidad de Antioquia, Hospital Universitario, San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-5641","authenticated-orcid":true,"given":"Sara","family":"Ram\u00edrez-Urrea","sequence":"additional","affiliation":[{"name":"General Medicine, Fundaci\u00f3n Universitaria San Mart\u00edn, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-9989","authenticated-orcid":true,"given":"Mar\u00eda C.","family":"Fragozo-Ramos","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Section, School of Medicine, Universidad de Antioquia, Endocrinology Department, Hospital San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5237-343X","authenticated-orcid":true,"given":"Jose E.","family":"Ag\u00e1mez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"General Medicine, Universidad de Antioquia, IPS UniversitariaCl\u00ednicaLe\u00f3n XIII, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5942-1035","authenticated-orcid":true,"given":"Alejandro","family":"Rom\u00e1n-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Endocrinology and Metabolism Section, School of Medicine, Universidad de Antioquia, Endocrinology Department, Hospital San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5301-9264","authenticated-orcid":true,"given":"Luis F.","family":"Arias","sequence":"additional","affiliation":[{"name":"Pathology Departament, Universidad de Antioquia, Hospital Universitario San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Benavides","family":"Arenas","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Universidad de Antioquia, Hospital Universitario, San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-2636","authenticated-orcid":true,"given":"Fernando","family":"L\u00f3pez-Urbano","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Universidad de Antioquia, Hospital Universitario, San Vicente Fundaci\u00f3n, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.5152\/UCD.2015.3032"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reumae.2011.06.002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102454"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-019-2257-7"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4248\/br201302005"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000211"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1530\/EDM-17-0041"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.06.322"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3450-3"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2018.0028"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.01322"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000327"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-021-06186-1"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2478\/enr-2021-0005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.08.006"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03346.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.1999.0027"},{"issue":"3","key":"18","first-page":"175","article-title":"The relationship between primary hyperparathyroidism and thrombotic events: report of three cases and a review of potential mechanisms","volume":"12","author":"T. Koufakis","year":"2018","journal-title":"International Journal of Hematology-Oncology and Stem Cell Research"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346669"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2008.04815.x"},{"issue":"2","key":"21","first-page":"101","article-title":"Primary hyperparathyroidism due to a giant parathyroid adenoma: a case report","volume":"9","author":"M. Salehian","year":"2009","journal-title":"International Journal of Endocrinology and Metabolism"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-011-0306-6"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-12-14"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2700.96497"},{"issue":"2Suppl","key":"25","first-page":"669","article-title":"Clinicopathologic and therapeutic aspects of giant parathyroid adenomas - three case reports and short review of the literature","volume":"55","author":"R. M. Neagoe","year":"2014","journal-title":"Romanian journal of morphology and embryology"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1308\/003588414X13946184900480"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1308\/003588415X14181254789682"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-016-1078-1"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.4103\/0972-3919.172355"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2017.01.064"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.12659\/ajcr.911452"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.04.003"},{"issue":"8","key":"33","first-page":"547","article-title":"Unusual ectopic parathyroid adenoma: a case report","volume":"54","author":"H. TaghaviKojidi","year":"2016","journal-title":"Acta Medica Iranica"},{"issue":"1","key":"34","first-page":"70","article-title":"Mediastinal giant parathyroid adenoma minimally invasive mediastinal surgical approach for an emergency presentation","volume":"5","author":"M. Pecheva","year":"2016","journal-title":"Annals of Cardiothoracic Surgery"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-220722"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2018.01.003"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-228292"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2020.0043"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.5603\/EP.a2020.0035"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2022\/3969542.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2022\/3969542.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2022\/3969542.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T14:50:19Z","timestamp":1643467819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crim\/2022\/3969542\/"}},"subtitle":[],"editor":[{"given":"Lothar","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,29]]},"references-count":39,"alternative-id":["3969542","3969542"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3969542","relation":{},"ISSN":["1687-9635","1687-9627"],"issn-type":[{"value":"1687-9635","type":"electronic"},{"value":"1687-9627","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,29]]}}}