{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T21:14:37Z","timestamp":1762809277207,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational Intelligence and Neuroscience"],"published-print":{"date-parts":[[2022,8,21]]},"abstract":"<jats:p>Objective. To investigate the effects of loratadine tablets in combination with other drugs on nasal physiological function and T lymphocyte subsets in patients with allergic rhinitis (AR). Methods. A total of 120 AR patients treated in our hospital from February 2018 to February 2021 were randomly divided into control group and research group. The control group was given mometasone furoate nasal spray combined with loratadine tablets, while the research group was given budesonide combined with loratadine. The efficacy, duration of clinical symptom remission, immune function indicators, T lymphocyte subset, nasal physiological function, and incidence of adverse reactions were compared between the two groups. Results. The efficacy results of the two groups showed that the effective rate of the research group was 96.67%, while the effective rate of the control group was 83.33%. The effective rate in the research group was higher compared to the control group (\u03c72: 5.925 <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The results of clinical symptom relief time showed that the clinical symptom relief time of nasal congestion, itching, runny nose, and sneezing in the research group was lower than that in the control group, and the difference was statistically significant (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The results of the comparison of immune function indicators showed that the IL-6, IL-8, and IgE of the research group were lower than those of the control group, while the Th1\/Th2 of the research group were higher than those of the control group. There were no statistically significant differences in T lymphocyte subsets before nursing, but after treatment, the T lymphocyte subsets of the two groups decreased, and the level of CD3+, CD4+, CD8+, CD4+, and CD4+\/CD8+ lymphocytes in the research group was lower than that of the control group, and the difference was statistically significant (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Before treatment, there exhibited no significant difference in nasal physiological function, but after treatment, the nasal physiological function of the two groups was enhanced, and the MTT, NR, and MCR of the research group were lower than those of the control group, and the difference was statistically significant (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Finally, the incidence of adverse reactions in the research group was lower compared to the control group, and the difference was statistically significant (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Conclusion. Budesonide and loratadine are effective in improving patient efficacy, T lymphocyte subsets, and nasal physiological function, and are safer.<\/jats:p>","DOI":"10.1155\/2022\/3990427","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T05:09:54Z","timestamp":1661144994000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Loratadine Tablets in Combination with Other Drugs on Nasal Physiological Function and T Lymphocyte Subsets in Patients with Allergic Rhinitis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"PuRen Hospital Affiliated to Wuhan University of Science and Technolog\/Otorhinolaryngology, No. 1 Benxi Street, Qingshan District, Wuhan City 430081, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"PuRen Hospital Affiliated to Wuhan University of Science and Technolog\/Otorhinolaryngology, No. 1 Benxi Street, Qingshan District, Wuhan City 430081, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"PuRen Hospital Affiliated to Wuhan University of Science and Technolog\/Otorhinolaryngology, No. 1 Benxi Street, Qingshan District, Wuhan City 430081, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Kan","sequence":"additional","affiliation":[{"name":"PuRen Hospital Affiliated to Wuhan University of Science and Technolog\/Otorhinolaryngology, No. 1 Benxi Street, Qingshan District, Wuhan City 430081, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-8016","authenticated-orcid":true,"given":"Yinghuai","family":"Wang","sequence":"additional","affiliation":[{"name":"PuRen Hospital Affiliated to Wuhan University of Science and Technolog\/Otorhinolaryngology, No. 1 Benxi Street, Qingshan District, Wuhan City 430081, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"S1","key":"1","first-page":"80","article-title":"Study on the efficacy of step-by-step antihistamine in the treatment of allergic rhinitis and its effect on the expression of inflammatory factors","volume":"38","author":"W. 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Chengyao","year":"2018","journal-title":"Chinese otorhinolaryngology head and neck surgery"},{"issue":"1","key":"28","first-page":"192","article-title":"Smoking attitudes of the patients with allergic rhinitis:a comparison withasthma and chronicobstructive pulmonary disease. Are theredifferences when only upper airwaysare involved?","volume":"66","author":"\u00c7. S. Zeynep","year":"2018","journal-title":"Tuberkuloz ve Toraks"},{"issue":"21","key":"29","first-page":"889","article-title":"Effect of budesonideandcetirizine hydrochlorideon neuro trophic factor, airway function and chemokines CCL17 and CCL22 in patientswithallergicrhinitis","volume":"23","author":"X. Xu","year":"2017","journal-title":"Journal of Hainan Medical University"},{"issue":"9","key":"30","first-page":"89","article-title":"Exploring The BurdenofIllnessandImpactofSQStandardisedGrassAllergyImmunotherapyTabletTreatment(AIT)onQualityofLife(QOL)inPatientswithAllergicRhinitis(AR)inGermanyandTheNetherlands","volume":"20","author":"N. Germain","year":"2017","journal-title":"ValueinHealth"},{"issue":"3","key":"31","first-page":"849","article-title":"Specificityandreproducibilityofnasalbiomarkersinpatientswithallergicrhinitisafterallergenchallengechamberexposure","volume":"118","author":"P. Badorrek","year":"2017","journal-title":"AnnalsofAllergy, Asthma&Immunology"}],"container-title":["Computational Intelligence and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cin\/2022\/3990427.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cin\/2022\/3990427.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cin\/2022\/3990427.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T05:10:22Z","timestamp":1661145022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cin\/2022\/3990427\/"}},"subtitle":[],"editor":[{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,21]]},"references-count":31,"alternative-id":["3990427","3990427"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3990427","relation":{},"ISSN":["1687-5273","1687-5265"],"issn-type":[{"type":"electronic","value":"1687-5273"},{"type":"print","value":"1687-5265"}],"subject":[],"published":{"date-parts":[[2022,8,21]]}}}