{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:32:28Z","timestamp":1779168748076,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Bethune Charitable Foundation","award":["flzh202114"],"award-info":[{"award-number":["flzh202114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,7,4]]},"abstract":"<jats:p>Thyroid dysfunction (TD) induced by programmed death-1 (PD-1) or programmed cell death-ligand 1 (PD-L1) immune checkpoint inhibitors (ICIs) has been widely reported. However, the effects of ICI-induced TD on the survival of patients with esophageal squamous cell carcinoma (ESCC) have not been described. Herein, a retrospective study was conducted, which 82 patients with advanced metastatic or recurrent ESCC treated with camrelizumab were enrolled. Twenty patients (24.4%) experienced TD during camrelizumab treatment with or without chemotherapy. The median onset time of TD was 1.7 months. The incidence of TD was 35.6% in patients who previously received thoracic radiotherapy versus 10.8% in patients who did not (P\u2009=0.009). Patients with TD had significantly longer median progression-free survival (5.5 months vs 3.5 months, P\u2009=0.035) and overall survival (26.7 months vs 11.5 months, P\u2009&lt;0.001). TD is frequently observed in ESCC patients treated with camrelizumab and especially in patients who received radiotherapy previously. ESCC patients with TD during ICIs treatment often have better prognosis.<\/jats:p>","DOI":"10.1155\/2022\/4015897","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T05:20:12Z","timestamp":1656998412000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["Thyroid Dysfunction as a Predictive Indicator in Camrelizumab of Advanced Esophageal Squamous Cell Carcinoma"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ying","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Thoracic Radiotherapy, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China"},{"name":"Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China"},{"name":"Key Laboratory Diagnosis & Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiotherapy, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China"},{"name":"Key Laboratory Diagnosis & Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang 310022, China"},{"name":"The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiotherapy, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China"},{"name":"Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China"},{"name":"Key Laboratory Diagnosis & Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghui","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiotherapy, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China"},{"name":"Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China"},{"name":"Key Laboratory Diagnosis & Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-7855","authenticated-orcid":true,"given":"Liming","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiotherapy, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China"},{"name":"Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China"},{"name":"Key Laboratory Diagnosis & Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang 310022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp069"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.03.017"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2017-0143"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.4410"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01730-x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30626-6"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01888"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30110-8"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.12836"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6385"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.08.022"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2925"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2468"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216954"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0116"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107296"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02802-6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.3064"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13297"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414428"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01234-4"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12119"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_148_19"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13175"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000739"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2017.11.002"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0064"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01480-6"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/4015897.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/4015897.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/4015897.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T05:20:16Z","timestamp":1656998416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2022\/4015897\/"}},"subtitle":[],"editor":[{"given":"Dawei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,4]]},"references-count":29,"alternative-id":["4015897","4015897"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4015897","relation":{},"ISSN":["2314-7156","2314-8861"],"issn-type":[{"value":"2314-7156","type":"electronic"},{"value":"2314-8861","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,4]]}}}