{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:58:54Z","timestamp":1785761934430,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":241,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KEMENRISTEK\/BRIN","award":["011\/SKP.TJ.PD\/LPPM\/IV\/2021"],"award-info":[{"award-number":["011\/SKP.TJ.PD\/LPPM\/IV\/2021"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Tuberculosis (TB) still remains the burden in Indonesia. One of the factors that may influence the treatment success of TB is patient\u2019s adherence. However, the hepatotoxicity of the TB medicine may decrease the patient\u2019s adherence. Our study\u2019s aim is to investigate the relationship between the patient's knowledge and the hepatotoxicity with medication adherence of TB patients in Banyumas Regency. This study was conducted at one Community Lung Health Center and two hospitals in Banyumas Regency, Purwokerto, Center of Java, Indonesia. The respondents were 91\u2009TB patients with hepatotoxicity characterized by an increased aspartate transaminase (AST) and alanine aminotransferase (ALT). The level of the patients\u2019 knowledge about the hepatotoxicity effect was determined using a questionnaire. The patients\u2019 adherence was determined using the Medication Adherence Rating Scale \u20105 (MARS) questionnaire and pill count methods. Most of the patients were male (53.8%), the age was in the range of 18\u201329\u2009years old (3.5%), they have no smoking history (59.3%), and their last education majorly was senior high school (46.2%). Most TB patients had poor knowledge (47.3%) and the hepatotoxic effect often appeared in grade 1 (61.5%). The TB patients with a good and moderate level of knowledge were 17.6% and 35.2%, respectively. The TB patients with moderate and severe hepatotoxicity were 39.4% and 1.1%, respectively. The measurement of the level of respondents\u2019 adherence using MARS\u20105 showed that 51.6% of patients had good adherence. We determined the rest of the drug\u2010using pill count method, which resulted in 62.6% of patients adhering to taking antituberculosis drugs. TB patients with a sufficient knowledge and those with mild hepatotoxicity show the higher adherence (<jats:italic>p<\/jats:italic> &lt; 0.001). There is a significant relationship between a high level of the patient\u2019s knowledge about hepatotoxicity effect, less severity of the hepatotoxic effect, and increased patient adherence in taking the medication.<\/jats:p>","DOI":"10.1155\/2022\/4044530","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T17:35:31Z","timestamp":1661880931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Investigating the Relationship between Knowledge and Hepatotoxic Effects with Medication Adherence of TB Patients in Banyumas Regency, Indonesia"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2638-6664","authenticated-orcid":false,"given":"Dyah A.","family":"Perwitasari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9104-548X","authenticated-orcid":false,"given":"Didik","family":"Setiawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7799-4523","authenticated-orcid":false,"given":"Thang","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1465-5561","authenticated-orcid":false,"given":"Arum","family":"Pratiwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5230-0326","authenticated-orcid":false,"given":"Laila","family":"Rahma Fauziah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9104-6079","authenticated-orcid":false,"given":"Erin","family":"Saebrinah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3551-1460","authenticated-orcid":false,"given":"Triantoro","family":"Safaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-988X","authenticated-orcid":false,"given":"Nunuk Aries","family":"Nurulita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-0035","authenticated-orcid":false,"given":"Idha","family":"Arfianti Wiraagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"e_1_2_9_1_2","unstructured":"WHO Global tuberculosis report 2019 https:\/\/www.who.int\/teams\/global-tuberculosis-programme\/tb-reports\/global-report-2019."},{"key":"e_1_2_9_2_2","unstructured":"Ministry of Health (Indonesia) Indonesia health profile 2019 https:\/\/pusdatin.kemkes.go.id\/resources\/download\/pusdatin\/profil-kesehatan-indonesia\/Profil-Kesehatan-indonesia-2019.pdf."},{"key":"e_1_2_9_3_2","unstructured":"WHO Global tuberculosis report 2021 https:\/\/www.who.int\/publications\/digital\/global-tuberculosis-report-2021."},{"key":"e_1_2_9_4_2","unstructured":"Anonymous Dashboard of tuberculosis in Indonesia 2021 https:\/\/tbindonesia.or.id\/pustaka-tbc\/dashboard-tb\/."},{"key":"e_1_2_9_5_2","unstructured":"Anonymous Badan pusat statistik provinsi D. 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