{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:43:27Z","timestamp":1787161407939,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2022,8,31]]},"abstract":"<jats:p>Central nervous system (CNS) involvement in multiple myeloma (MM) (MM-CNS) in the form of leptomeningeal myelomatosis or brain parenchyma plasmacytoma is rare, causing challenges in clinical diagnosis and treatment. We would like to report a case of leptomeningeal myelomatosis and illustrated the challeges. A 61-year-old man was diagnosed with  MM with left paravertebral plasmacytoma, R-ISS II with high suspicion of double-hit MM, either biallelic aberrancy of TP53 or del(17p) and IGH aberrancy depending on the definition chosen, treated with lenalidomide-bortezomib-dexamethasone and local radiotherapy, later developed systemic relapse and progression to MM-CNS in the form of leptomeningeal myelomatosis. A modified CNS-based treatment not reported before, consisting of daratumumab, pomalidomide, vincristine, procarbazine, and dexamethasone, brought a rapid clinical improvement and warrants a further study. Incorporation of intrathecal thiotepa into the regimen would likely increase the efficacy.<\/jats:p>","DOI":"10.1155\/2022\/4081971","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T15:35:09Z","timestamp":1661960109000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["A Case Report of Leptomeningeal Myelomatosis and Rapid Improvement with Regimen Consisting of Daratumumab, Pomalidomide, Vincristine, Procarbazine, and Dexamethasone"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1686-5570","authenticated-orcid":true,"given":"Jew Win","family":"Kuan","sequence":"first","affiliation":[{"name":"Department of Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sing Ling","family":"Chai","sequence":"additional","affiliation":[{"name":"Timberland Medical Centre, Kuching, Sarawak, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9199-1940","authenticated-orcid":true,"given":"Pathmanathan","family":"Rajadurai","sequence":"additional","affiliation":[{"name":"Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Gong","family":"Lau","sequence":"additional","affiliation":[{"name":"Borneo Medical Centre, Kuching, Sarawak, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7925-4622","authenticated-orcid":true,"given":"Joseph","family":"Uchang","sequence":"additional","affiliation":[{"name":"Borneo Medical Centre, Kuching, Sarawak, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharifah Noor Akmal","family":"Syed Husain","sequence":"additional","affiliation":[{"name":"Pantai Premier Pathology Sdn Bhd, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26447"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.248518"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(16)30206-6"},{"key":"4","volume-title":"VELCADE (Bortezomib) for Injection","author":"U.S. Food and Drug Administration","year":"2008"},{"key":"5","volume-title":"REVLIMID (Lenalidomide) Capsules, for Oral Use","author":"U.S. Food and Drug Administration","year":"2019"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0196-8"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62885-0"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.023697"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.168872"},{"issue":"8","key":"11","first-page":"1342","article-title":"Detection of p53 mutations in hematological malignancies: comparison between immunocytochemistry and DNA analysis","volume":"8","author":"P. 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