{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:49:20Z","timestamp":1782283760205,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":114,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Osteoarthritis (OA) is one of the age\u2010related diseases and is highly present on the knees. Obesity and mechanical injuries as a risk factor of OA are attributed to cartilage disintegration, joint loading, and inflammation. This study is aimed at investigating the effects of seahorse protein hydrolysate (SH) on posttraumatic osteoarthritis in an obesity rat. The OA model was developed by anterior cruciate ligament transection with medial meniscectomy in a high\u2010fat diet\u2010 (HFD\u2010) induced obesity rat model. The male Sprague\u2010Dawley rats were fed a HFD for 6 weeks before OA surgery. The OA rats were treated with oral gavage by 4, 8, or 20\u2009mg\/kg of body weight of SH for 6 weeks of treatment. The expressions of plasma proinflammatory factors, C\u2010telopeptide of type II collagen, and matrix metalloproteinase\u2010 (MMP\u2010) 3 and MMP\u201013 were reduced by SH treatment. Plasma superoxide dismutase and glutathione peroxidase activities were enhanced by SH. SH also relieved the pain of the knee joint and swelling as well as decreased proteoglycan loss in the knee articular cartilage caused by osteoarthritis. Based on these results, SH suppressed proinflammatory factors and attenuated cartilage degradation and pain in the OA model. Therefore, seahorse protein hydrolysate might be a potential opportunity for improving the development of osteoarthritis.<\/jats:p>","DOI":"10.1155\/2022\/4117520","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T03:35:07Z","timestamp":1650944107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Seahorse Protein Hydrolysate Ameliorates Proinflammatory Mediators and Cartilage Degradation on Posttraumatic Osteoarthritis with an Obesity Rat Model"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-3772","authenticated-orcid":false,"given":"Sabri","family":"Sudirman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-0521","authenticated-orcid":false,"given":"Po-Sheng","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2821-6597","authenticated-orcid":false,"given":"Chun-Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3153-5484","authenticated-orcid":false,"given":"David","family":"Tsou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4877-6524","authenticated-orcid":false,"given":"Zwe-Ling","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203355"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34453"},{"key":"e_1_2_8_3_2","first-page":"205","article-title":"Knee osteoarthritis prevalence, risk factors, pathogenesis and features: part I","volume":"2","author":"Heidari B.","year":"2011","journal-title":"Caspian Journal of Internal Medicine"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.16884"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-013-9454-x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162022"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.12.013"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/boneres.2015.40"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v3.i2.89"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.4081\/idhm.2021.158"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2012.662650"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.12.003"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.10.019"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.5657\/FAS.2012.0029"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111760"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13765-016-0237-9"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.08.007"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/s30800276"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90167-9"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203260"},{"key":"e_1_2_8_21_2","first-page":"185","article-title":"Obesity &amp; osteoarthritis","volume":"138","author":"King L. 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