{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:22:58Z","timestamp":1792621378533,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Exceptional Young Talents Fostering Foundation 2021 of the Tianjin Fourth Central Hospital","award":["tjdszxyy20210004"],"award-info":[{"award-number":["tjdszxyy20210004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2022,8,13]]},"abstract":"<jats:p>Objective. We aimed to clarify the efficacy of dapagliflozin versus liraglutide in patients with overweight or obesity and type 2 diabetes mellitus (T2DM) at the beginning of the coronavirus disease 2019 (COVID-19) pandemic. Methods. T2DM patients with overweight or obesity who visited the Metabolic Disease Management Center at Tianjin Fourth Central Hospital from October 2019 to January 2020 were recruited and randomised to receive dapagliflozin or liraglutide for 24 weeks. Changes in blood glucose and lipid levels, blood pressure, and body weight, as well as the occurrence of hypoglycaemia and other adverse events, were compared. Results. 309 patients completed the study (143 in liraglutide group and 166 in dapagliflozin group). After 24 weeks, HbA1c, fasting blood glucose (FPG), and 2\u2009h postprandial blood glucose (2hPG) levels significantly decreased from <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mn>8.80<\/a:mn>\n                        <a:mi>%<\/a:mi>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mn>1.41<\/a:mn>\n                        <a:mi>%<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula> to <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mn>7.02<\/c:mn>\n                        <c:mi>%<\/c:mi>\n                        <c:mo>\u00b1<\/c:mo>\n                        <c:mn>1.05<\/c:mn>\n                        <c:mi>%<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mn>10.41<\/e:mn>\n                        <e:mo>\u00b1<\/e:mo>\n                        <e:mn>3.13<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula> to <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mn>7.59<\/g:mn>\n                        <g:mo>\u00b1<\/g:mo>\n                        <g:mn>2.16<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009mmol\/L, and <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mn>17.90<\/i:mn>\n                        <i:mo>\u00b1<\/i:mo>\n                        <i:mn>4.39<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula> to <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mn>10.12<\/k:mn>\n                        <k:mo>\u00b1<\/k:mo>\n                        <k:mn>2.47<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>\u2009mmol\/L, respectively, in the dapagliflozin group, and from <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mn>8.92<\/m:mn>\n                        <m:mi>%<\/m:mi>\n                        <m:mo>\u00b1<\/m:mo>\n                        <m:mn>1.49<\/m:mn>\n                        <m:mi>%<\/m:mi>\n                     <\/m:math>\n                  <\/jats:inline-formula> to <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mn>6.78<\/o:mn>\n                        <o:mi>%<\/o:mi>\n                        <o:mo>\u00b1<\/o:mo>\n                        <o:mn>1.00<\/o:mn>\n                        <o:mi>%<\/o:mi>\n                     <\/o:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mn>10.04<\/q:mn>\n                        <q:mo>\u00b1<\/q:mo>\n                        <q:mn>2.99<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula> to <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mn>7.20<\/s:mn>\n                        <s:mo>\u00b1<\/s:mo>\n                        <s:mn>1.63<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>\u2009mmol\/L, and <jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mn>17.30<\/u:mn>\n                        <u:mo>\u00b1<\/u:mo>\n                        <u:mn>4.39<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula> to <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mn>10.13<\/w:mn>\n                        <w:mo>\u00b1<\/w:mo>\n                        <w:mn>4.15<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>\u2009mmol\/L, respectively, in the liraglutide group. Changes in HbA1c, FPG, and 2hPG levels between groups were not significantly different. Systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C) level significantly decreased from <jats:inline-formula>\n                     <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <y:mn>144.1<\/y:mn>\n                        <y:mo>\u00b1<\/y:mo>\n                        <y:mn>19.1<\/y:mn>\n                     <\/y:math>\n                  <\/jats:inline-formula> to <jats:inline-formula>\n                     <ab:math xmlns:ab=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\">\n                        <ab:mn>139.7<\/ab:mn>\n                        <ab:mo>\u00b1<\/ab:mo>\n                        <ab:mn>16.2<\/ab:mn>\n                     <\/ab:math>\n                  <\/jats:inline-formula>\u2009mmHg (<jats:inline-formula>\n                     <cb:math xmlns:cb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\">\n                        <cb:mi>p<\/cb:mi>\n                        <cb:mo>=<\/cb:mo>\n                        <cb:mn>0.001<\/cb:mn>\n                     <\/cb:math>\n                  <\/jats:inline-formula>) and from <jats:inline-formula>\n                     <eb:math xmlns:eb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\">\n                        <eb:mn>3.21<\/eb:mn>\n                        <eb:mo>\u00b1<\/eb:mo>\n                        <eb:mn>0.94<\/eb:mn>\n                     <\/eb:math>\n                  <\/jats:inline-formula> to <jats:inline-formula>\n                     <gb:math xmlns:gb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M17\">\n                        <gb:mn>2.98<\/gb:mn>\n                        <gb:mo>\u00b1<\/gb:mo>\n                        <gb:mn>0.89<\/gb:mn>\n                     <\/gb:math>\n                  <\/jats:inline-formula>\u2009mmol\/L (<jats:inline-formula>\n                     <ib:math xmlns:ib=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M18\">\n                        <ib:mi>p<\/ib:mi>\n                        <ib:mo>=<\/ib:mo>\n                        <ib:mn>0.014<\/ib:mn>\n                     <\/ib:math>\n                  <\/jats:inline-formula>), respectively, in the dapagliflozin group. After COVID-19 outbreak, the number of patients taking sleep-promoting drugs increased from 4.9% to 9.4% (<jats:inline-formula>\n                     <kb:math xmlns:kb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M19\">\n                        <kb:mi>p<\/kb:mi>\n                        <kb:mo>=<\/kb:mo>\n                        <kb:mn>0.029<\/kb:mn>\n                     <\/kb:math>\n                  <\/jats:inline-formula>). Conclusions. Liraglutide and dapagliflozin had strong hypoglycaemic effects in patients with overweight or obesity and T2DM at the beginning of the COVID-19 pandemic. Dapagliflozin may be beneficial in improving SBP and LDL-C levels; however, further research is warranted.<\/jats:p>","DOI":"10.1155\/2022\/4126995","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T20:05:05Z","timestamp":1660421105000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy and Safety of Dapagliflozin versus Liraglutide in Patients with Overweight or Obesity and Type 2 Diabetes Mellitus: A Randomised Controlled Clinical Trial in Tianjin, China"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3965-3805","authenticated-orcid":true,"given":"Hao","family":"Zhaohu","sequence":"first","affiliation":[{"name":"Department of Metabolic Disease Management Center, Tianjin 4th Central Hospital, 300140 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Xiao","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin 300134, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3279-9542","authenticated-orcid":true,"given":"Shao","family":"Hailin","sequence":"additional","affiliation":[{"name":"Department of Metabolic Disease Management Center, Tianjin 4th Central Hospital, 300140 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3286-8309","authenticated-orcid":true,"given":"He","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin 4th Central Hospital, 300140 Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m997"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.9.2130"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1515130"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-020-00927-6"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218178"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S242148"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00191"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.39342"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13830"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2498"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1902837"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-0312-7"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30369-7"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911303"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03263-6"},{"issue":"2","key":"16","first-page":"95","article-title":"Guideline 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