{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:11:56Z","timestamp":1767168716283,"version":"build-2238731810"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,4,8]]},"abstract":"\n Objective. Traditional Chinese medicine (TCM) has been used to treat Parkinson\u2019s disease (PD), but the efficacy is still not clear. The aim of this study was to evaluate the effect of the integrated Chinese and Western medicine (ICWM) for PD through a meta-analysis. Methods. We searched randomized controlled trials comparing integrated Chinese and Western medicine (ICWM) versus conventional Western medicine (CWM) for Parkinson\u2019s disease. Data were extracted from eligible studies. We sought to evaluate pretreatment and posttreatment symptoms of PD patients and their quality of life and reduce adverse reactions. The results were expressed as risk ratio (RR) and mean difference (MD) with accompanying 95% confidence intervals. Results. Twenty-three studies were included in this study with a total of 1769 patients. The pooled results revealed that ICWM significantly improved the UPDRS score than CWM, the MD of UPDRS-I, II, III, and IV was -1.05 (95% CI: -1.42 to -0.69,\n \n \n P<\/a:mi>\n <<\/a:mo>\n 0.00001<\/a:mn>\n <\/a:math>\n <\/jats:inline-formula>\n ), -2.55 (95% CI: -3.19 to -1.90,\n \n \n P<\/c:mi>\n <<\/c:mo>\n 0.00001<\/c:mn>\n <\/c:math>\n <\/jats:inline-formula>\n ), -3.64 (95% CI: -4.69 to -2.60,\n \n \n P<\/e:mi>\n <<\/e:mo>\n 0.00001<\/e:mn>\n <\/e:math>\n <\/jats:inline-formula>\n ), and -0.61 (95% CI: -0.96 to -0.27,\n \n \n P<\/g:mi>\n =<\/g:mo>\n 0.0004<\/g:mn>\n <\/g:math>\n <\/jats:inline-formula>\n ), respectively, and ICWM also had a better score of PDQ-39 (\n \n \n MD<\/i:mtext>\n =<\/i:mo>\n \u2212<\/i:mo>\n 8.71<\/i:mn>\n <\/i:math>\n <\/jats:inline-formula>\n , 95% CI: -13.52 to -3.90,\n \n \n P<\/k:mi>\n =<\/k:mo>\n 0.0004<\/k:mn>\n <\/k:math>\n <\/jats:inline-formula>\n ) and MoCA scores (\n \n \n MD<\/m:mtext>\n =<\/m:mo>\n 3.35<\/m:mn>\n <\/m:math>\n <\/jats:inline-formula>\n , 95% CI: 1.65 to 5.04,\n \n \n P<\/o:mi>\n =<\/o:mo>\n 0.0001<\/o:mn>\n <\/o:math>\n <\/jats:inline-formula>\n ) compared with CWM. ICWM had certain advantages in terms of effective rate (\n \n \n RR<\/q:mtext>\n =<\/q:mo>\n 1.27<\/q:mn>\n <\/q:math>\n <\/jats:inline-formula>\n , 95% CI: 1.18 to 1.37,\n \n \n P<\/s:mi>\n <<\/s:mo>\n 0.00001<\/s:mn>\n <\/s:math>\n <\/jats:inline-formula>\n ) and adverse reactions (\n \n \n RR<\/u:mtext>\n =<\/u:mo>\n 0.21<\/u:mn>\n <\/u:math>\n <\/jats:inline-formula>\n , 95% CI: 0.13 to 0.36,\n \n \n P<\/w:mi>\n <<\/w:mo>\n 0.00001<\/w:mn>\n <\/w:math>\n <\/jats:inline-formula>\n ). Conclusion. Our research supported that ICWM had important health benefits for patients with PD and can effectively improve the symptoms of PD patients and their quality of life and reduce adverse reactions. Due to the lower quality of the included studies, large sample and multicenter randomized control test should be performed to verify our conclusions.\n <\/jats:p>","DOI":"10.1155\/2022\/4134931","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T21:20:08Z","timestamp":1649452808000},"page":"1-11","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of the Integrated Chinese and Western Medicine for the Treatment of Parkinson\u2019s Disease: A Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Zengmian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jiamusi University, Jiamusi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianshu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The First Affiliated Hospital of Jiamusi University, Jiamusi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoying","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Jiamusi University, Jiamusi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-9968","authenticated-orcid":true,"given":"Pengcheng","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Yakeshi Zhongmeng Hospital, Hulunbuir, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-017-1788-5","article-title":"Parkinson's disease: experimental models and reality","volume":"135","author":"P. 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Janet","year":"2019","journal-title":"Expert Opin Pharmaco"},{"key":"5","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/j.1460-9568.2005.03969.x","article-title":"Levodopa-induced modulation of subthalamic beta oscillations during self-paced movements in patients with Parkinson's disease","volume":"21","author":"L. M. F. Doyle","year":"2015","journal-title":"The European Journal of Neuroscience"},{"key":"6","first-page":"1083","article-title":"Treatment of Parkinson's disease with amantadine and levodopa","volume":"1","author":"J. D. Parkes","year":"2018","journal-title":"A one-year study. Lancet"},{"key":"7","first-page":"1232","article-title":"Pharmacological chaperone design for reducing risk factor of Parkinson's disease from traditional Chinese medicine","volume":"34","author":"H. J. 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Kaplitt","year":"2015","journal-title":"Lancet"},{"key":"39","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1468-1331.2004.00804.x","article-title":"Improvement in quality of life in patients with advanced Parkinson's disease following bilateral deep-brain stimulation in subthalamic nucleus","volume":"11","author":"E. Lezcano","year":"2015","journal-title":"European Journal of Neurology the Official Journal of the European Federation of Neurological Societies"},{"key":"40","article-title":"Chinese herbal medicine paratherapy for Parkinson's disease: a meta-analysis of 19 randomized controlled trials","volume":"2012, article 534861","author":"Y. Wang","year":"2012","journal-title":"Evidence-Based Complementray and Alternative Medicine"},{"key":"41","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1142\/S0192415X14500657","article-title":"Systematic review of traditional Chinese medicine for depression in Parkinson's disease","volume":"42","author":"Y. 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Tian","year":"2019","journal-title":"Journal of Tianjin University of traditional Chinese Medicine"}],"updated-by":[{"DOI":"10.1155\/2023\/9818050","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"record-id":"56418"},{"DOI":"10.1155\/2023\/9818050","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/4134931.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/4134931.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/4134931.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T21:20:45Z","timestamp":1649452845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2022\/4134931\/"}},"subtitle":[],"editor":[{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,8]]},"references-count":43,"alternative-id":["4134931","4134931"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4134931","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,8]]}}}