{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T13:49:53Z","timestamp":1787492993520,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":147,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660696"],"award-info":[{"award-number":["81660696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Cydonia oblonga<\/jats:italic> Mill. (COM), mature fruit of genus Rosaceae, is consumed as a kind of traditional Chinese medicinal herb. Previous studies have shown that the components in COM extract have antioxidant, anti\u2010inflammatory, blood pressure\u2010lowering, blood lipid\u2010lowering, antithrombotic, and other biological activities. However, the quality markers (Q\u2010markers) of atherosclerosis (AS) have not been elucidated. The Q\u2010marker is based on the five core principles of traceability, transferability, specificity, measurability, validity, and prescription dispensing. In this study, the quality markers of quince were investigated by applying the ultraperformance liquid chromatography\u2010time\u2010of\u2010flight mass spectrometry (UHPLC\/Q\u2010TOF\u2010MS\/MS) method and network pharmacology method to highlight the three core elements which are, respectively, traceability transmission, measurability, and validity. At the first step, 72 components were identified by applying the ultraperformance liquid chromatography\u2010time\u2010of\u2010flight mass spectrometry (UHPLC\/Q\u2010TOF\u2010MS\/MS) method. In the next step, 46 candidate components of COM anti\u2010AS were obtained by network pharmacology, and then, 27 active components were filtered with the molecular docking assay. Finally, the 27 active components were intersected with 10 active components obtained by mass transfer and traceable quality markers. Four anti\u2010AS Q\u2010markers of COM were identified, including caffeic acid, chlorogenic acid, ellagic acid, and vanillic acid, which provided a reference for the quality control of quince. The methods and strategies can also be applied to other traditional Chinese medicines and their compound preparations, providing new ideas on the quantitative evaluation and identification of quality markers.<\/jats:p>","DOI":"10.1155\/2022\/4176235","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T03:50:07Z","timestamp":1653796207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["UHPLC\u2010Q\u2010TOF\u2010MS\/MS and Network Pharmacology Analysis to Reveal Quality Markers of Xinjiang <i>Cydonia oblonga<\/i> Mill. for Antiatherosclerosis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-9684","authenticated-orcid":false,"given":"Jimilihan","family":"Simayi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-7949","authenticated-orcid":false,"given":"Abulaiti","family":"Abulizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3419-7027","authenticated-orcid":false,"given":"Maimaitiming","family":"Nuermaimaiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-6877","authenticated-orcid":false,"given":"Nawaz","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5867-8744","authenticated-orcid":false,"given":"Sendaer","family":"Hailati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4145-1820","authenticated-orcid":false,"given":"Mengyuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-4539","authenticated-orcid":false,"given":"Ziruo","family":"Talihati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8683-8837","authenticated-orcid":false,"given":"Kayisaier","family":"Abudurousuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8242-0062","authenticated-orcid":false,"given":"Nulibiya","family":"Maihemuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-4181","authenticated-orcid":false,"given":"Muhadaisi","family":"Nuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2610-7634","authenticated-orcid":false,"given":"Wenting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-8163","authenticated-orcid":false,"given":"Ainiwaer","family":"Wumaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"153","article-title":"Cardiotonic drugs from the Avicenna\u2019s point of view","volume":"44","author":"Ghorbani F.","year":"2015","journal-title":"Iranian Journal of Public Health"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf304969b"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1553877"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.01.018"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.03.014"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.12.010"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.03.056"},{"key":"e_1_2_10_8_2","first-page":"1443","article-title":"Q-marker: a new concept for quality control of traditional Chinese medicine products","volume":"47","author":"Liu C. 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