{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:33Z","timestamp":1787017773869,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":136,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774320"],"award-info":[{"award-number":["81774320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    This study is to verify the effect of asthma on sperm quality and explore its potential underlying mechanism. We randomly categorized the Sprague\u2010Dawley (SD) rats into control (Group C) and asthma model (Group M) groups. Rats in the asthma model group were induced allergic asthma by intraperitoneal injection of ovalbumin solution. We evaluated the sperm motility and sperm concentration. The expression of the Interleukin\u20106 (IL6), phosphorylation\u2010signal transducer and activator of transcription 3 (p\u2010Stat3), and hypoxia\u2010inducible factor\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ) proteins and mRNAs in the testicular tissue was detected by western blotting and RT\u2010qPCR. Compared with group C, sperm concentration and sperm motility in group M rats were significantly decreased (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Meanwhile, compared with group C, the expression levels of IL6, Stat3, and HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    proteins and mRNAs in group M rats were significantly increased (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Asthma can regulate the HIF\u20101 signaling pathway, promoting the expression of IL6, Stat3, and HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    protein and mRNAs, so as to promote sperm apoptosis and ultimately causing male infertility.\n                  <\/jats:p>","DOI":"10.1155\/2022\/4194685","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T20:05:08Z","timestamp":1652817908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Explore the Effect of Asthma Regulating HIF\u20101 Pathway on Sperm Quality Based on Rat Model"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-6586","authenticated-orcid":false,"given":"Junlong","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3284-7463","authenticated-orcid":false,"given":"Yuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-7053","authenticated-orcid":false,"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-5693","authenticated-orcid":false,"given":"Binghao","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9493-723X","authenticated-orcid":false,"given":"Yichen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-5579","authenticated-orcid":false,"given":"Sheng","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6306-2570","authenticated-orcid":false,"given":"Haisong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-6837","authenticated-orcid":false,"given":"Jiangbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-7932","authenticated-orcid":false,"given":"Jisheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14940"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-9-4"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00511.2020"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.08.003"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.01.002"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.02.004"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0203OC"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.170370"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0032-1"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00417-9"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.023085"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2004.00651.x"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.05013"},{"key":"e_1_2_10_14_2","first-page":"368","article-title":"Effect of high altitude exposure on spermatogenesis and epididymal sperm count in male rats","volume":"35","author":"Gasco M.","year":"2003","journal-title":"Andrologia"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/and.14348"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-017-0359-2"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw937"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-8-S4-S11"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.08.041"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27665"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113810"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00193-3"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.04.005"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-017-0448-0"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr9007927"},{"key":"e_1_2_10_28_2","first-page":"355","article-title":"New progress in the study of the relationship between IL-6\/IL-6 receptor and rheumatoid arthritis","volume":"27","author":"Miao P.","year":"2011","journal-title":"Journal of Immunology"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040391"},{"key":"e_1_2_10_30_2","first-page":"161","article-title":"Interleukin-6 expression during normal maturation of the mouse testis","volume":"16","author":"Potashnik H.","year":"2005","journal-title":"European Cytokine Network"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00048"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.03.051"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep28012"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.097386"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.007153"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.115093"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/4194685.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/4194685.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/4194685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T15:47:02Z","timestamp":1735660022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/4194685"}},"subtitle":[],"editor":[{"given":"Mohammad Amin","family":"Abdollahifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/4194685"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4194685","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4194685"}}