{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:29:49Z","timestamp":1779910189368,"version":"3.53.1"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,1,24]]},"abstract":"<jats:p>Sepsis is a systemic inflammatory response syndrome caused by viral infection. The circulatory dysfunction caused by sepsis is also called septic shock or septic shock. The main characteristics are rapid onset, rapid changes, and involvement. Multiple organs in the body make diagnosis difficult, which seriously threatens the survival of patients. As many as one million people worldwide die every year because of SIRS, it is also the leading cause of death among children in hospital ICUs. This article is aimed at studying the clinical characteristics of severe sepsis in children and the risk factors for death. Based on the analysis of the pathogenesis of sepsis and the treatment of septic shock, 65 cases of children with PICU sepsis admitted to a hospital were selected. Data, to study its clinical characteristics and risk factors for death. The results of the study showed that despite the interaction among the removal factors of the three indexes of serum lactic acid value, PCIS level, and the number of organs involved in MODS, they are still related to the mortality of children with severe sepsis.<\/jats:p>","DOI":"10.1155\/2022\/4200605","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T16:20:49Z","timestamp":1643041249000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Characteristics and Death Risk Factors of Severe Sepsis in Children"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neonatology, Xiangyang No.1 People\u2019s Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buqing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Renhe Hospital of China Three Gorges University, Yichang, Hubei 443000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Miao","sequence":"additional","affiliation":[{"name":"Emergency Department, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9839-6418","authenticated-orcid":true,"given":"Lihui","family":"Wu","sequence":"additional","affiliation":[{"name":"Emergency Department, Children\u2019s Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"3","key":"1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"C. 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Samuels","year":"2018","journal-title":"Surgical Infections"},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pedneo.2017.06.001","article-title":"Clinical characteristics and epidemiology of sepsis in the neonatal intensive care unit in the era of multi-drug resistant organisms: a retrospective review","volume":"59","author":"D. Yusef","year":"2018","journal-title":"Pediatrics & Neonatology"},{"issue":"21","key":"11","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1001\/jama.2018.6229","article-title":"Association of the Quick Sequential (sepsis-related) Organ Failure Assessment (qSOFA) score with excess hospital mortality in adults with suspected infection in low- and middle-income countries","volume":"319","author":"K. E. 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