{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:30:46Z","timestamp":1771482646331,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":261,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Erodium guttatum<\/jats:italic> is widely used in folk medicine in many countries to treat various ailments such as urinary inflammation, diabetes, constipation, and eczema. The aim of this study is the determination of mineral and phenolic compounds of <jats:italic>E. guttatum<\/jats:italic> extracts as well as the investigation of their antidiabetic and antioxidant properties. The mineral composition was determined by the methods of inductively coupled plasma atomic emission spectroscopy analysis. Phytochemical contents of total polyphenols, total flavonoids, and catechic tannins were estimated by colorimetric dosages. The phenolic composition was identified by high\u2010resolution mass spectrometry (HRMS) analysis. The antioxidant activity of <jats:italic>E. guttatum<\/jats:italic> extracts was measured <jats:italic>in vitro<\/jats:italic> by five methods (DPPH, ABTS, FRAP, H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, and xanthine oxidase) and <jats:italic>in vivo<\/jats:italic> by assaying the malondialdehyde marker (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). The obtained results showed that the root plant material is rich in minerals such as k, Ca, and Mg. The methanolic extract of <jats:italic>E. guttatum<\/jats:italic> is the richest in polyphenols (389.20 \u00b1 1.55\u2009mg EAG\/gE), tannins (289.70 \u00b1 3.57\u2009mg EC\/gE), and flavonoids (432.5 \u00b1 3.21\u2009mg ER\/gE). Concerning the ESI\u2010HRMS analysis, it showed the presence of numerous bioactive compounds, including shikimic acid, rottlerine, gallic acid, and vanillic acid. Moreover, the aqueous and alcoholic extracts of <jats:italic>E. guttatum<\/jats:italic> exhibited antiradical and antioxidant activity in five tests used, with the best effect of the methanolic extract. Moreover, findings showed that <jats:italic>in vivo<\/jats:italic> investigations confirmed those obtained <jats:italic>in vitro.<\/jats:italic> On the other hand, <jats:italic>E. guttatum<\/jats:italic> showed important antidiabetic effects <jats:italic>in vivo<\/jats:italic>. Indeed, diabetic mice treated with extracts of <jats:italic>E. guttatum<\/jats:italic> were able to significantly reduce MDA levels and increase the secretion of enzymatic and nonenzymatic antioxidants (SOD, CAT, and GSH, respectively). However, the antioxidant activity of the extracts might be attributed to the abundance of bioactive molecules; as results, this work serves as a foundation for additional pharmacological research.<\/jats:p>","DOI":"10.1155\/2022\/4229981","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T23:20:18Z","timestamp":1663629618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mineral and Phenolic Composition of <i>Erodium guttatum<\/i> Extracts and Investigation of Their Antioxidant Properties in Diabetic Mice"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1391-6232","authenticated-orcid":false,"given":"Kaoutar","family":"Benrahou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-2572","authenticated-orcid":false,"given":"Hanae 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