{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:10:14Z","timestamp":1792509014503,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017959","name":"Health Commission of Hebei Province","doi-asserted-by":"publisher","award":["20201331"],"award-info":[{"award-number":["20201331"]}],"id":[{"id":"10.13039\/100017959","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,8,10]]},"abstract":"<jats:p>Objective. To study the correlation between serum sclerostin (SO) and arterial stiffness in peritoneal dialysis (PD) patients. Methods. The study included 50 Parkinson\u2019s disease (PD) patients on continuous ambulatory peritoneal dialysis (CAPD) for more than 6 months at the nephrology department of our hospital. Without regard for age, the eligible patients were assigned to a low PWV group and a high PWV group with brachial-ankle pulse wave velocity (Ba PWV) of 1400\u2009cm\/s as the cutoff value. Patient characteristics such as age, gender, height, weight, BMI, smoking history, dialysis age, systolic blood pressure (SBP), diastolic blood pressure (DBP), urea clearance index (Kt\/V), residual renal function (RRF), and diabetes mellitus (DM) were analyzed. Biochemical indices for analysis include hemoglobin (Hb), albumin (ALB), total cholesterol (TC), urea nitrogen (BUN), creatinine (CREA), triglyceride (TG), uric acid (UA), parathyroid hormone (PTH), blood phosphorus(P), fasting blood glucose (GLU), corrective calcium (Ca), calcium-phosphorus product, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), SO, and arterial stiffness. Results. There were 9 males and 16 females in the low PWV group and 12 males and 13 females in the high PWV group. Statistical significance was absent in patient characteristics despite more males in the high PWV group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.055<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The low PWV group had significantly lower mean age, SBP, SO, and PWV level, fewer diabetic patients, and higher CREA than the control group. Analysis of PWV-related factors showed that PWV was positively correlated with age, P, Ca, GLU, SBP, PTH, and SO while negatively correlated with CREA. Multiple stepwise regression analysis showed that age, SO, and SBP demonstrated great potential to predict PWV (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Conclusion. The degree of vascular sclerosis is highly correlated with SO level in Parkinson\u2019s disease patients, which might provide a theoretical basis for the evaluation of cardiovascular illness in Parkinson\u2019s disease patients. High serum sclerostin level is a risk factor for deteriorated arterial stiffness. Given the limited sample size, the relevant results require further validation by expanding the sample size.<\/jats:p>","DOI":"10.1155\/2022\/4247782","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T21:05:10Z","timestamp":1660165510000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["The Correlation between Serum Sclerostin Level and Arterial Stiffness in Peritoneal Dialysis Patients"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5463-6395","authenticated-orcid":true,"given":"Fang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Kidney Diseases, Shexian Hospital of Traditional Chinese Medicine, Huangshan, Hebei, China"},{"name":"Medical Department, Shexian Hospital of Traditional Chinese Medicine, Huangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Ma","sequence":"additional","affiliation":[{"name":"Laboratory, Shexian Hospital of Traditional Chinese Medicine, Huangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shexian Hospital of Traditional Chinese Medicine, Huangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Function, Shexian Hospital of Traditional Chinese Medicine, Huangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Kidney Diseases, Shexian Hospital of Traditional Chinese Medicine, Huangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Science and Teach, Shexian Hospital of Traditional Chinese Medicine, Huangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12694"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-020-01449-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy174"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-018-00577-9"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.04.019"},{"issue":"05","key":"6","first-page":"3030","article-title":"Efficacy of renal failure formula combined with Western medicine in the treatment of maintenance peritoneal dialysis patients","volume":"36","author":"J. 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