{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:20:42Z","timestamp":1781076042211,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean Government","award":["NRF-2021R1A2C1007718"],"award-info":[{"award-number":["NRF-2021R1A2C1007718"]}]},{"name":"Ministry of Health & Welfare","award":["NRF-2021R1A2C1007718"],"award-info":[{"award-number":["NRF-2021R1A2C1007718"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,9,7]]},"abstract":"<jats:p>Purpose. To analyze the clinical characteristics and prognosis of optic neuritis (ON) in pediatric patients aged &lt;19 years in South Korea. Methods. This multicenter retrospective cohort study included 127 pediatric patients (median age: 10.3 (IQR: 7.3\u201314.2) years; female, 62.2%) who experienced ON for the first time between January 2004 and January 2018, with data obtained from five tertiary university-based hospitals in Korea. When ON was bilateral, the worse eye was selected for analysis. The baseline clinical characteristics and prognoses of patients, as well as the associations between these parameters, were analyzed. Results. The baseline clinical characteristics of the patients were as follows: best-corrected visual acuity (BCVA)\u2009&lt;\u200920\/200, 65.9%; pain on eye movement, 47.2%; optic disc swelling, 66.9%; and bilateral involvement, 41.7%. Among 101 patients who were followed up for \u22656 months, 48 (47.5%), 12 (11.9%), 19 (18.8%), 13 (12.9%), and 9 (8.9%) had been diagnosed with isolated ON, recurrent ON, multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and acute disseminated encephalomyelitis (ADEM)-related ON, respectively. At the latest visit, 81.9% and 71.1% had achieved BCVA of \u226520\/40 and\u2009\u2265\u200920\/25, respectively. Only disc swelling at presentation was associated with poor baseline BCVA (coefficient: 0.31,<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><a:mo>=<\/a:mo><a:mn>0.004<\/a:mn><\/a:math><\/jats:inline-formula>) and greater improvement in BCVA (coefficient: 0.49, P\u2009=\u20090.001<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>P<\/c:mi><c:mo>=<\/c:mo><c:mn>0.001<\/c:mn><\/c:math><\/jats:inline-formula>); there were no significant associations between the baseline factors and final BCVA. Conclusions. This study demonstrated pediatric ON-related clinical characteristics and visual outcomes in South Korea. Within this cohort, in about 40.6% of patients, ON was associated with other demyelinating diseases, namely, MS, NMOSD, and ADEM.<\/jats:p>","DOI":"10.1155\/2022\/4281772","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T20:05:08Z","timestamp":1662581108000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Characteristics of Optic Neuritis in South Korean Children and Adolescents: A Retrospective Multicenter Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7907-5635","authenticated-orcid":true,"given":"Kyung-Ah","family":"Park","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-6036","authenticated-orcid":true,"given":"Hee Kyung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8607-6625","authenticated-orcid":true,"given":"Jinu","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Vision Research, Gangnam Severance Hospital, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7944-6990","authenticated-orcid":true,"given":"Seong-Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Institute of Vision Research, Severance Hospital, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haeng-Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jeonbuk National University College of Medicine, Jeonju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sueng-Han","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Vision Research, Severance Hospital, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei Yeul","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-2864","authenticated-orcid":true,"given":"Jeong-Min","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"5","key":"1","first-page":"1236","article-title":"Optic neuritis","volume":"25","author":"J. 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