{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T18:45:51Z","timestamp":1781030751378,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017534","name":"Inner Mongolia Medical University","doi-asserted-by":"publisher","award":["NYFY BS 202102"],"award-info":[{"award-number":["NYFY BS 202102"]}],"id":[{"id":"10.13039\/100017534","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017534","name":"Inner Mongolia Medical University","doi-asserted-by":"publisher","award":["ZY 0130013"],"award-info":[{"award-number":["ZY 0130013"]}],"id":[{"id":"10.13039\/100017534","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2022,3,20]]},"abstract":"<jats:p>Background. Several studies have assessed the diagnostic accuracy of pleural fluid soluble interleukin-2 receptor (sIL-2R) for tuberculous pleural effusion (TPE) but with varied results. Therefore, we conducted this systematic review and meta-analysis to evaluate the accuracy of sIL-2R for TPE. Methods. PubMed, Ovid, and Web of Science databases were searched from inception to 23 March 2021 to identify eligible studies concerning the diagnostic accuracy of fluid sIL-2R for TPE. The sensitivity and specificity of sIL-2R for TPE were pooled with a bivariate model. We estimated the global diagnostic accuracy of PE sIL-2R with a summary receiver operating characteristic (sROC) curve. The revised Quality Assessment for Diagnostic Accuracy Studies tool (QUADAS-2) was used to assess the quality of eligible studies. Results. A total of nine studies with 270 TPEs and 586 non-TPEs were included in the final analysis. The pooled sensitivity and specificity were 0.81 (95% CI: 0.76\u20130.86) and 0.92 (95% CI: 0.77\u20130.98), respectively. The area under the sROC curve (AUC) was 0.82 (95% CI: 0.79\u20130.86). No significant publication bias was observed. Conclusions. Pleural fluid sIL-2R is a useful diagnostic marker for TPE. However, the diagnostic accuracies of already available biomarkers such as pleural fluid adenosine deaminase, interferon-\u03b3, and interleukin-27 appear to be superior relative to sIL-2R. Therefore, it might not be preferable to use sIL-2R for diagnosing TPE.<\/jats:p>","DOI":"10.1155\/2022\/4348063","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:05:10Z","timestamp":1647810310000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Pleural Fluid Soluble Interleukin-2 Receptor as a Biomarker for the Diagnosis of Tuberculosis Pleural Effusion: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0946-4413","authenticated-orcid":true,"given":"Zhi","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Parasitology, The Basic Medical Sciences College of Inner Mongolia Medical University, Hohhot 010050, China"},{"name":"Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0746-0523","authenticated-orcid":true,"given":"Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Parasitology, The Basic Medical Sciences College of Inner Mongolia Medical University, Hohhot 010050, China"},{"name":"Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-3768","authenticated-orcid":true,"given":"Wen-Qi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Parasitology, The Basic Medical Sciences College of Inner Mongolia Medical University, Hohhot 010050, China"},{"name":"Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-4992","authenticated-orcid":true,"given":"Zhi-De","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2014.03.012"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13673"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2018.11.006"},{"issue":"19","key":"4","first-page":"3563","article-title":"Evaluation of a diagnostic flow chart applying medical thoracoscopy, adenosine deaminase and T-SPOT.TB in diagnosis of tuberculous pleural effusion","volume":"19","author":"Y. 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