{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:41:02Z","timestamp":1787913662384,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Fund Project of People\u2019s Hospital of Guangxi Zhuang Autonomous Region","award":["YXQNRC 2018-2"],"award-info":[{"award-number":["YXQNRC 2018-2"]}]},{"name":"Youth Fund Project of People\u2019s Hospital of Guangxi Zhuang Autonomous Region","award":["Guike AD21220134"],"award-info":[{"award-number":["Guike AD21220134"]}]},{"DOI":"10.13039\/501100009329","name":"Guangxi Science and Technology Planning Project","doi-asserted-by":"crossref","award":["YXQNRC 2018-2"],"award-info":[{"award-number":["YXQNRC 2018-2"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009329","name":"Guangxi Science and Technology Planning Project","doi-asserted-by":"crossref","award":["Guike AD21220134"],"award-info":[{"award-number":["Guike AD21220134"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2022,2,12]]},"abstract":"<jats:p>Intervertebral disc degeneration (IDD) is considered the basis of serious clinical symptoms, especially for low back pain (LBP). Therefore, it is essential to explore the regulatory role and diagnostic performance of dysregulated genes and potential drugs in IDD. Through WGCNA co-expression analysis, 36 co-expression modules were obtained. Among them, MidnightBlue and Red modules were the most related to IDD. Functional enrichment analysis showed that the Red module was mainly related to neutrophil activation and regulation of cytokine-mediated signaling pathway and apoptosis, whereas the MidnightBlue module was mainly related to extracellular matrix organization, bone development, extracellular matrix, extracellular matrix component, and other extracellular matrices. Furthermore, 356 genes highly related to the module were screened to construct a protein interaction network. Network degree distribution analysis showed that the known IDD-related genes had a higher degree of distribution. Enrichment analysis demonstrated that these genes were enriched in MAPK_SIGNALING_PATHWAY (FDR\u2009=\u20090.012), CHEMOKINE_SIGNALING_PATHWAY, and some other pathways. By constructing a disease-gene interaction network, three disease-specific genes were finally identified. Through combining with the drug-target gene interaction network, two potential therapeutic drugs, entrectinib and larotrectinib, were determined. Finally, based on these genes, the diagnostic model in the training dataset, test dataset, and verification dataset all showed a high diagnostic performance. The findings of this study contributed to the diagnosis of IDD and personalized treatment of IDD.<\/jats:p>","DOI":"10.1155\/2022\/4407541","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T17:50:09Z","timestamp":1644688209000},"page":"1-17","source":"Crossref","is-referenced-by-count":13,"title":["Comprehensive Network Analysis Identified SIRT7, NTRK2, and CHI3L1 as New Potential Markers for Intervertebral Disc Degeneration"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1810-0045","authenticated-orcid":true,"given":"Haoxi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Third People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicheng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuhai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-4342","authenticated-orcid":true,"given":"Qie","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-4106","authenticated-orcid":true,"given":"Jianxun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s12976-015-0020-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.09.019"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.343"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204428"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(11)60610-7"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2011.06.001"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-8-63"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1253"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-008-0873-9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-011-0596-y"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1177\/1947603520973247"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2020-0101"},{"key":"13","first-page":"3160","article-title":"lncRNA\/circRNA-miRNA-mRNA ceRNA network in lumbar intervertebral disc degeneration","volume":"20","author":"J. Zhu","year":"2019","journal-title":"Molecular Medicine Reports"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1021"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-1923-x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21195"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa563"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13551"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyw078"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00652"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/nature08197"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.01.129"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202009_23006"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5337-y"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2018.12.005"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1177\/147323000903700102"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.02.007"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.7029"},{"key":"30","first-page":"705","article-title":"Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1\/2 study","volume-title":"The Lancet Oncology","author":"T. W. Laetsch","year":"2019"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-1044-x"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(19)30856-3"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0465-5"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.8137"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn429"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq675"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm369"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2451-4"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2022\/4407541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2022\/4407541.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2022\/4407541.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T17:50:15Z","timestamp":1644688215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jo\/2022\/4407541\/"}},"subtitle":[],"editor":[{"given":"Fu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,12]]},"references-count":42,"alternative-id":["4407541","4407541"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4407541","relation":{},"ISSN":["1687-8469","1687-8450"],"issn-type":[{"value":"1687-8469","type":"electronic"},{"value":"1687-8450","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,12]]}}}