{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:01:40Z","timestamp":1791558100618,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Rijeka","award":["Uni-ri-biomed-18-160"],"award-info":[{"award-number":["Uni-ri-biomed-18-160"]}]},{"name":"University of Rijeka","award":["Uni-ri-biomed-18-110"],"award-info":[{"award-number":["Uni-ri-biomed-18-110"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,6,3]]},"abstract":"We aimed to evaluate the diagnostic accuracy of the proinflammatory monocyte chemotactic protein-1 (MCP-1) in the diagnosis of asymptomatic diastolic dysfunction (DD) in patients with psoriatic arthritis (PsA). The disease activity in psoriatic arthritis (DAPSA) was determined using clinical and laboratory parameters, and echocardiography was performed to estimate DD. Serum MCP-1 concentrations were elevated in PsA patients with DD diagnosed with ultrasound (median (25th percentile, 75th percentile): 366.6\u2009pg\/mL (283, 407.1\u2009pg\/mL) vs. 277.5\u2009pg\/mL (223.5, 319.1\u2009pg\/mL) in controls; \n \n P<\/a:mi>\n <<\/a:mo>\n 0.0017<\/a:mn>\n <\/a:math>\n <\/jats:inline-formula>). PsA patients with serum MCP-1 concentration higher than the cut-off value of 347.6\u2009pg\/mL had a 7.74-fold higher chance of developing DD than PsA patients with lower serum MCP-1 concentrations (controls), with a specificity of 86.36% and sensitivity of 55%, as verified using ultrasound. The group with MCP-1 concentrations above the cut-off value also showed a higher late peak diastolic mitral inflow velocity, A-wave value (\n \n P<\/c:mi>\n =<\/c:mo>\n 0.000005<\/c:mn>\n <\/c:math>\n <\/jats:inline-formula>), E\/E\n \n \n \n \n \u2032<\/e:mo>\n <\/e:mrow>\n <\/e:msup>\n <\/e:math>\n <\/jats:inline-formula> ratio (\n \n P<\/g:mi>\n =<\/g:mo>\n 0.00005<\/g:mn>\n <\/g:math>\n <\/jats:inline-formula>), and a lower E\/A ratio (\n \n P<\/i:mi>\n =<\/i:mo>\n 0.000002<\/i:mn>\n <\/i:math>\n <\/jats:inline-formula>), peak systolic left atrial reservoir strain, SA value (\n \n P<\/k:mi>\n =<\/k:mo>\n 0.0066<\/k:mn>\n <\/k:math>\n <\/jats:inline-formula>), early peak diastolic displacement of the mitral septal annulus, E\n \n \n \n \n \u2032<\/m:mo>\n <\/m:mrow>\n <\/m:msup>\n <\/m:math>\n <\/jats:inline-formula> wave value (\n \n P<\/o:mi>\n =<\/o:mo>\n 0.003<\/o:mn>\n <\/o:math>\n <\/jats:inline-formula>), than controls. Systolic blood pressure (\n \n P<\/q:mi>\n =<\/q:mo>\n 0.01<\/q:mn>\n <\/q:math>\n <\/jats:inline-formula>), LDL cholesterol concentration (\n \n P<\/s:mi>\n =<\/s:mo>\n 0.012<\/s:mn>\n <\/s:math>\n <\/jats:inline-formula>), glucose concentration (\n \n P<\/u:mi>\n =<\/u:mo>\n 0.011<\/u:mn>\n <\/u:math>\n <\/jats:inline-formula>), and DAPSA (\n \n P<\/w:mi>\n =<\/w:mo>\n 0.0000<\/w:mn>\n <\/w:math>\n <\/jats:inline-formula>) increased in the PsA group with higher MCP-1 concentrations, although there were no differences in comorbidities and therapy between the groups compared. Thus, the serum MCP-1 concentration was a significant and independent prognostic indicator for asymptomatic DD in PsA patients (\n \n area<\/y:mtext>\n \u2009<\/y:mtext>\n under<\/y:mtext>\n \u2009<\/y:mtext>\n the<\/y:mtext>\n \u2009<\/y:mtext>\n curve<\/y:mtext>\n =<\/y:mo>\n 0.730<\/y:mn>\n <\/y:math>\n <\/jats:inline-formula>, \n \n P<\/ab:mi>\n =<\/ab:mo>\n 0.001<\/ab:mn>\n <\/ab:math>\n <\/jats:inline-formula>). The DAPSA score in PsA patients might indicate the need for echocardiography and adjustment of anti-inflammatory treatment in terms of DD prevention.<\/jats:p>","DOI":"10.1155\/2022\/4433313","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T20:20:16Z","timestamp":1654287616000},"page":"1-12","source":"Crossref","is-referenced-by-count":2,"title":["Predictive Value of Monocyte Chemoattractant Protein-1 in the Development of Diastolic Dysfunction in Patients with Psoriatic Arthritis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1050-0135","authenticated-orcid":true,"given":"Iva Uravi\u0107","family":"Bursa\u0107","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital for Medical Rehabilitation of Hearth and Lung Diseases and Rheumatism \u201cThalassotherapia-Opatija\u201d, M. Tita 188, 51420 Opatija, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-5263","authenticated-orcid":true,"given":"Tatjana","family":"Kehler","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital for Medical Rehabilitation of Hearth and Lung Diseases and Rheumatism \u201cThalassotherapia-Opatija\u201d, M. Tita 188, 51420 Opatija, Croatia"},{"name":"Department of Medical Rehabilitation, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-856X","authenticated-orcid":true,"given":"Vedrana","family":"Drvar","sequence":"additional","affiliation":[{"name":"Clinical Department of Laboratory Diagnostics, Clinical Hospital Centre Rijeka, Tome Stri\u017ei\u0107a 3, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1787-2177","authenticated-orcid":true,"given":"Emina","family":"Babarovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia"},{"name":"Clinical Department of Pathology, Clinical Hospital Center Rijeka, Kre\u0161imirova 42, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-7999","authenticated-orcid":true,"given":"Vesna Pehar","family":"Pej\u010dinovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital for Medical Rehabilitation of Hearth and Lung Diseases and Rheumatism \u201cThalassotherapia-Opatija\u201d, M. Tita 188, 51420 Opatija, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-3363","authenticated-orcid":true,"given":"Antonija Ru\u017ei\u0107","family":"Bar\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital for Medical Rehabilitation of Hearth and Lung Diseases and Rheumatism \u201cThalassotherapia-Opatija\u201d, M. Tita 188, 51420 Opatija, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-5431","authenticated-orcid":true,"given":"Viktor","family":"Per\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital for Medical Rehabilitation of Hearth and Lung Diseases and Rheumatism \u201cThalassotherapia-Opatija\u201d, M. Tita 188, 51420 Opatija, Croatia"},{"name":"Department of Medical Rehabilitation, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-155X","authenticated-orcid":true,"given":"Gordana","family":"Laskarin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital for Medical Rehabilitation of Hearth and Lung Diseases and Rheumatism \u201cThalassotherapia-Opatija\u201d, M. 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