{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:46:58Z","timestamp":1761324418300,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:p>Preeclampsia (PE) is a common and proprietary complication during pregnancy. The correlation was found between the levels of HtrA3 and TGF-\u03b2 2 and preeclampsia (PE). This study aimed to detect the HtrA3 and TGF-\u03b22 in different parts of the third trimester (maternal serum, placenta). The 102 pregnant women who were eligible for enrollment in the obstetric examination at Tengzhou Maternity and Child Health Hospital from June 2020 to December 2020 were selected as the research objects. 28 cases diagnosed with PE were set up as the observation group 1, and 24 cases diagnosed with severe PE were set up as the observation group 2. Select 50 normal pregnant women as the control group and research the expressions of HtrA3 and TGF-\u03b22 in maternal blood and placental tissues of patients with PE. ELISA was used to measure the concentration of HtrA3 and TGF-\u03b22 in maternal blood. The distribution of HtrA3 and TGF-\u03b22 in the placenta was observed by immunohistochemical techniques (IHC) and mean optical density value (MOD). S\/D was measured by using color Doppler ultrasonic. The concentration of HtrA3 and TGF-\u03b22 in the maternal blood and placenta tissue was higher in severe PE compared with PE and normotensive pregnancy, respectively (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). There is a negative correlation between the level of HtrA3 and TGF-\u03b22 and the birthweight of newborns both in maternal plasma and placenta tissue in preeclampsia and positive correlation between HtrA3 and TGF-\u03b22 levels and S\/D. HtrA3 and TGF-\u03b22 may correlate with severity of PE and their neonatal adverse outcomes.<\/jats:p>","DOI":"10.1155\/2022\/4453646","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T16:51:08Z","timestamp":1641574268000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Study on the Correlation between the Levels of HtrA3 and TGF-\u03b22 in Late Pregnancy and Preeclampsia"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8787-9991","authenticated-orcid":true,"given":"Wenying","family":"Huang","sequence":"first","affiliation":[{"name":"Xuzhou Medical University, Xuzhou 221000, Jiangsu, China"},{"name":"Department of Obstetrics, Tengzhou Maternity and Child Health Hospital, Tengzhou 277500, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-5685","authenticated-orcid":true,"given":"Shuxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Xuzhou First People\u2019s Hospital Affiliated to Xuzhou Medical University, Xuzhou 221004, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy","volume":"72","author":"M. A. Brown","year":"2018","journal-title":"Hypertension"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46699-3"},{"issue":"2","key":"3","first-page":"185","article-title":"The expression of TGF-\u03b22 and TGF\u03b2RII in the placenta of preeclampsia","volume":"41","author":"X. Yang","year":"2016","journal-title":"Journal of Guiyang Medical College"},{"issue":"9","key":"4","first-page":"876","article-title":"The feasibility analysis of the second trimester serum index combined with the cord blood flow S\/D value in the third trimester to predict fetal growth restriction","volume":"41","author":"X. Ru","year":"2020","journal-title":"Journal of Chinese People's Liberation Army Medical College"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0119-6"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m114.576744"},{"issue":"6","key":"7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1159\/000497144","article-title":"Low serum levels of HtrA3 at 15 Weeks of gestation are associated with late-onset preeclampsia development and small for gestational age birth","volume":"46","author":"T. S. S. Yee","year":"2019","journal-title":"Fetal Diagnosis Theory"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1177\/1087057116682425"},{"first-page":"1","article-title":"The expression of TGF-\u03b22 in the placenta of preeclampsia and normal pregnancy","author":"Z. Li","key":"9"},{"issue":"1","key":"10","first-page":"1","article-title":"The role of uterine and umbilical arterial Doppler in high-risk pregnancy: a prospective observational study from Indiana","volume":"9","author":"T. Nagar","year":"2015","journal-title":"Clinical Medicine Insights Reproduction Health"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.07.348"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04867-3"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051008"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2021.07.03"}],"container-title":["Journal of Healthcare Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/4453646.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/4453646.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/4453646.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T16:51:15Z","timestamp":1641574275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jhe\/2022\/4453646\/"}},"subtitle":[],"editor":[{"given":"Kalidoss","family":"Rajakani","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,7]]},"references-count":14,"alternative-id":["4453646","4453646"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4453646","relation":{},"ISSN":["2040-2309","2040-2295"],"issn-type":[{"type":"electronic","value":"2040-2309"},{"type":"print","value":"2040-2295"}],"subject":[],"published":{"date-parts":[[2022,1,7]]}}}