{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:23:40Z","timestamp":1790198620588,"version":"4.1.0"},"reference-count":152,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":180,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104561"],"award-info":[{"award-number":["82104561"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017634","name":"Henan University of Chinese Medicine","doi-asserted-by":"publisher","award":["00104311-2020-1"],"award-info":[{"award-number":["00104311-2020-1"]}],"id":[{"id":"10.13039\/100017634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M682311"],"award-info":[{"award-number":["2020M682311"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a potent tumor suppressor that regulates several key cellular processes, including proliferation, survival, genomic integrity, migration, and invasion, via PI3K\u2010dependent and independent mechanisms. A subtle decrease in PTEN levels or catalytic activity is implicated not only in cancer but also in a wide spectrum of other diseases, including various respiratory diseases. A systemic overview of the advances in the molecular and cellular mechanisms of PTEN involved in the initiation and progression of respiratory diseases may offer novel targets for the development of effective therapeutics for the treatment of respiratory diseases. In the present review, we highlight the novel findings emerging from current research on the role of PTEN expression and regulation in airway pathological conditions such as asthma\/allergic airway inflammation, pulmonary hypertension (PAH), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and other acute lung injuries (ALI). Moreover, we discuss the clinical implications of PTEN alteration and recently suggested therapeutic possibilities for restoration of PTEN expression and function in respiratory diseases.<\/jats:p>","DOI":"10.1155\/2022\/4512503","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T22:05:14Z","timestamp":1656626714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["PTEN: An Emerging Potential Target for Therapeutic Intervention in Respiratory Diseases"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9922-6389","authenticated-orcid":false,"given":"Bangrong","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-9645","authenticated-orcid":false,"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1209-6786","authenticated-orcid":false,"given":"Young","family":"Do Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3672-3345","authenticated-orcid":false,"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-1328","authenticated-orcid":false,"given":"Xinguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-7303","authenticated-orcid":false,"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6485-2371","authenticated-orcid":false,"given":"Jiansheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21357"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-10574-w"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130182"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03693-7"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5308.1943"},{"key":"e_1_2_8_6_2","first-page":"2124","article-title":"TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta","volume":"57","author":"Li D. M.","year":"1997","journal-title":"Cancer Research"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0497-356"},{"key":"e_1_2_8_8_2","first-page":"1820","article-title":"Differential expression of MMAC\/PTEN in glioblastoma multiforme: relationship to localization and prognosis","volume":"59","author":"Sano T.","year":"1999","journal-title":"Cancer Research"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65040-7"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01404.2000"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64624-X"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234907"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.023"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14771"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2500-6"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.150203"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002138"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5369.1614"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2828"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3399"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9388"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22965"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0015-0"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a036095"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.02.006"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081141"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90408-G"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16440"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3309fje"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.022228"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-47"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-011-0264-x"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.12.104"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000539"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1484-7"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103664"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106911"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.05.031"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219081"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12260"},{"key":"e_1_2_8_41_2","first-page":"173","article-title":"TGF-\u03b21 induces airway smooth muscle cell proliferation and remodeling in asthmatic mice by up-regulating miR-181a and suppressing PTEN","volume":"12","author":"Lv X.","year":"2019","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2015.1090501"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.038"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148821"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040875"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2019.07.001"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S291333"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.8998"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.040"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2155"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201205-0851OC"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10779"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108712"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200901-0100OC"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707501"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2008.00020.x"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00037.2011"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-015-8639-z"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120677"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163250"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000438"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.109"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01595-7"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.097"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aai9085"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01612"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.646546"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1871394"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2019.1568240"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.18838"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69281-8"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161669"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2664"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101544"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12545"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202210"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2017.08.011"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0500-x"},{"key":"e_1_2_8_79_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00382.2016"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112050"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201810-1975TR"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep35871"},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2013.10.004"},{"key":"e_1_2_8_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110016"},{"key":"e_1_2_8_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(02)00052-4"},{"key":"e_1_2_8_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.06.016"},{"key":"e_1_2_8_87_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-209389"},{"key":"e_1_2_8_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90493-6"},{"key":"e_1_2_8_89_2","first-page":"108","article-title":"Measurements of transepithelial electric potential differences in the trachea and bronchi of human subjects in vivo","volume":"126","author":"Knowles M. R.","year":"1982","journal-title":"The American Review of Respiratory Disease"},{"key":"e_1_2_8_90_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20203"},{"key":"e_1_2_8_91_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.159434"},{"key":"e_1_2_8_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201500171"},{"key":"e_1_2_8_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep26048"},{"key":"e_1_2_8_94_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/573210"},{"key":"e_1_2_8_95_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102262"},{"key":"e_1_2_8_96_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12858"},{"key":"e_1_2_8_97_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200507-1058OC"},{"key":"e_1_2_8_98_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091117"},{"key":"e_1_2_8_99_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080001"},{"key":"e_1_2_8_100_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535370215600100"},{"key":"e_1_2_8_101_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0286-3"},{"key":"e_1_2_8_102_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.4852"},{"key":"e_1_2_8_103_2","doi-asserted-by":"publisher","DOI":"10.3109\/08977194.2015.1109511"},{"key":"e_1_2_8_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.02.037"},{"key":"e_1_2_8_105_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9TX00019D"},{"key":"e_1_2_8_106_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606450200"},{"key":"e_1_2_8_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.07.020"},{"key":"e_1_2_8_108_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061017"},{"key":"e_1_2_8_109_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094616"},{"key":"e_1_2_8_110_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00079.2015"},{"key":"e_1_2_8_111_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0377OC"},{"key":"e_1_2_8_112_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035926"},{"key":"e_1_2_8_113_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-041OC"},{"key":"e_1_2_8_114_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2004-0126oc"},{"key":"e_1_2_8_115_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100446"},{"key":"e_1_2_8_116_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.07.21"},{"key":"e_1_2_8_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.01.017"},{"key":"e_1_2_8_118_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12506"},{"key":"e_1_2_8_119_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10053"},{"key":"e_1_2_8_120_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0902-0"},{"key":"e_1_2_8_121_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9614"},{"key":"e_1_2_8_122_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-011-9332-z"},{"key":"e_1_2_8_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.02.007"},{"key":"e_1_2_8_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09707-y"},{"key":"e_1_2_8_125_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S104627"},{"key":"e_1_2_8_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116928"},{"key":"e_1_2_8_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.185"},{"key":"e_1_2_8_128_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000188"},{"key":"e_1_2_8_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.06.006"},{"key":"e_1_2_8_130_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00514"},{"key":"e_1_2_8_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2017.10.009"},{"key":"e_1_2_8_132_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3292"},{"key":"e_1_2_8_133_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b14-00610"},{"key":"e_1_2_8_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107223"},{"key":"e_1_2_8_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.08.037"},{"key":"e_1_2_8_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152942"},{"key":"e_1_2_8_137_2","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2010.524722"},{"key":"e_1_2_8_138_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-128801"},{"key":"e_1_2_8_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.02.001"},{"key":"e_1_2_8_140_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1283-1"},{"key":"e_1_2_8_141_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184422"},{"key":"e_1_2_8_142_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-0262-1"},{"key":"e_1_2_8_143_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-021-04127-z"},{"key":"e_1_2_8_144_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00134"},{"key":"e_1_2_8_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.010"},{"key":"e_1_2_8_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.05.021"},{"key":"e_1_2_8_147_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.06.09"},{"key":"e_1_2_8_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.01.022"},{"key":"e_1_2_8_149_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0586-2"},{"key":"e_1_2_8_150_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12773"},{"key":"e_1_2_8_151_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-208964"},{"key":"e_1_2_8_152_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13026"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/4512503.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/4512503.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/4512503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T23:41:08Z","timestamp":1748907668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/4512503"}},"subtitle":[],"editor":[{"given":"Vinicius F.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":152,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/4512503"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4512503","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4512503"}}