{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:12:32Z","timestamp":1767168752058,"version":"build-2238731810"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":108,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CIK Cell Immunotherapy for Non-Small Cell Lung Cancer","award":["2017ZC058"],"award-info":[{"award-number":["2017ZC058"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    To study the mechanism of circular ribonucleic acid (RNA) circHIPK3 involved in the resistance of lung cancer cells to gefitinib, 110 patients with lung cancer were recruited as the research objects, and the tumor tissue and para\u2010cancerous tissue of each patient\u2019s surgical specimens were collected and paraffinized to detect the expression of circHIPK3 in different tissues. Gefitinib drug\u2010resistant cell line of lung cancer was constructed with gefitinib to detect cell apoptosis under different conditions. As a result, the relative expression of circHIPK3 in patients with tumor diameter no less than 3\u2009cm was dramatically inferior to that in patients with tumor diameter less than 3\u2009cm (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). The relative expression of circHIPK3 in patients with TNM stage II\/III was dramatically inferior to that in patients with tumor, node, and metastasis (TNM) stage I (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Expression of circHIPK3 in patients with lymph node metastasis was dramatically inferior to that in patients without lymph node metastasis (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Of the lung cancer tissues of patients with different TNM stages, only six patients had high expression, and the remaining 104 patients had low expression. Moreover, electrophoresis revealed that circHIPK3 can only be amplified in cDNA, but not in gDNA. Gefitinib\u2010mediated apoptosis rate of lung cancer drug\u2010resistant cell lines decreased notably. In summary, the circular RNA circHIPK3 may have a notably low expression in lung cancer tissues, whose low expression had a certain enhancement effect on the drug resistance of lung adenocarcinoma cells to gefitinib.\n                  <\/jats:p>","DOI":"10.1155\/2022\/4541918","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T17:05:50Z","timestamp":1650387950000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["[Retracted] Mechanism of RNA circHIPK3 Involved in Resistance of Lung Cancer Cells to Gefitinib"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yi","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2590-4498","authenticated-orcid":false,"given":"Qiugan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1515553"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01245-4"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.084"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01221-6"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20527-z"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22980"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2230-9"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0943-0"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1634945"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01390-w"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0889-7"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01648-1"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800654"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-020-00503-x"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118955"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1514"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.172"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202007_21892"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.04.172"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0455-x"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.2775"},{"key":"e_1_2_9_22_2","first-page":"7565","article-title":"Correlation between histone H3K4 trimethylation and DNA methylation and evaluation of the metabolomic features in acute rejection after kidney transplantation","volume":"12","author":"Zhang Y.","year":"2020","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.08.012"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-018-1502-7"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202003_20519"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13274"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2127-7"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1061-8"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1111-2"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.153144"}],"updated-by":[{"DOI":"10.1155\/2024\/9895649","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"record-id":"66848"},{"DOI":"10.1155\/2024\/9895649","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000}}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/4541918.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/4541918.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/4541918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T03:38:53Z","timestamp":1735616333000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/4541918"}},"subtitle":[],"editor":[{"given":"Yingbin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/4541918"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4541918","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4541918"}}