{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:06:10Z","timestamp":1793747170938,"version":"4.6.1"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The First Affiliated Hospital of Chengdu Medical College","award":["CYFY2019ZD05"],"award-info":[{"award-number":["CYFY2019ZD05"]}]},{"name":"The First Affiliated Hospital of Chengdu Medical College","award":["81901379"],"award-info":[{"award-number":["81901379"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CYFY2019ZD05"],"award-info":[{"award-number":["CYFY2019ZD05"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901379"],"award-info":[{"award-number":["81901379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,5,31]]},"abstract":"<jats:p>Methylenetetrahydrofolate reductase (MTHFR) is a critical rate-limiting enzyme in the homocysteine\/methionine metabolism pathway that is implicated in the pathogenesis and progression of autoimmune diseases. Previous association studies have been performed to investigate the effect of polymorphisms in MTHFR on the risk of autoimmune diseases with inconsistent results. Therefore, this meta-analysis was designed to assess the association between the MTHFR 677 C\/T and 1298 A\/C polymorphisms and the susceptibility to autoimmune diseases. We identified reports by a literature search in the following electronic databases: PubMed, Ovid, Web of science, and China National Knowledge Infrastructure. Statistical analyses of the summary odds ratios (ORs) and 95% confidence intervals (CIs) were done using STATA software. In a recessive genetic model, the MTHFR 677 C\/T polymorphism was associated with an increased risk of Behcet\u2019s disease (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>OR<\/a:mtext>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>1.97<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, 95% CI, 1.31-2.97), multiple sclerosis (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>OR<\/c:mtext>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>1.57<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, 95% CI, 1.03-2.38), and ankylosing spondylitis (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>OR<\/e:mtext>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>2.90<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, 95% CI, 1.92-4.38). The MTHFR 1298 A\/C polymorphism was associated an increased risk of multiple sclerosis in a heterozygote comparison (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mtext>OR<\/g:mtext>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>2.36<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, 95% CI, 1.29-4.30) and in a dominant model (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mtext>OR<\/i:mtext>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>2.31<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, 95% CI, 1.24-4.29). This meta-analysis demonstrated that the MTHFR 677 C\/T was a risk factor for Behcet\u2019s disease, multiple sclerosis, and ankylosing spondylitis, and the 1298 A\/C was a risk factor for multiple sclerosis.<\/jats:p>","DOI":"10.1155\/2022\/4568145","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T03:05:06Z","timestamp":1654052706000},"page":"1-24","source":"Crossref","is-referenced-by-count":19,"title":["Association between Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Risk of Autoimmune Diseases: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8508-823X","authenticated-orcid":true,"given":"Mao","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, China"},{"name":"School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-161X","authenticated-orcid":true,"given":"Ke","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, China"},{"name":"School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6191-6157","authenticated-orcid":true,"given":"Li","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7171-724X","authenticated-orcid":true,"given":"Li","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0427-9542","authenticated-orcid":true,"given":"Peng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-895X","authenticated-orcid":true,"given":"Yundan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/90935"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12395"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.09.008"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/01.NUMA.0000455740.32485.9c"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.07.698"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200303000-00002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/965385"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1654754"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(90)90070-2"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2019.31.4.378"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.42058"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207068"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0875-x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1972-1"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1055\/a-0643-4692"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-111"},{"issue":"5","key":"17","first-page":"1052","article-title":"Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype\/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency","volume":"56","author":"P. 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Klotz","year":"2010","journal-title":"Neuroscience Letters"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.02.025"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.5114\/fn.2019.83829"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2012.04646.x"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1694"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/4568145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/4568145.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/4568145.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T03:05:26Z","timestamp":1654052726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/4568145\/"}},"subtitle":[],"editor":[{"given":"Zhengwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,31]]},"references-count":61,"alternative-id":["4568145","4568145"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4568145","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,31]]}}}