{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:03:05Z","timestamp":1761238985953,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,6,2]]},"abstract":"<jats:p>Introduction. Considering oral rehabilitation with dental implants, many studies have aimed at improving bone regeneration through the use of biomaterials. Objective. This study aimed at comparing bone neoformation in patients undergoing bilateral maxillary sinus surgery with two bovine biomaterials. Materials and Methods. This is a randomized, blinded, clinical crossover, and divided mouth study. Ten participants with an indication of maxillary sinus enlargement were selected and underwent surgical treatment with Bio-Oss\u00ae graft biomaterial (graft 1) on one side and Lumina-Porous\u00ae graft biomaterial (graft 2) on the other. The samples were collected after nine months and fixed and then decalcified in 10% ethylenediamine tetra-acetic acid (EDTA) solution for 30 days to process and make histological slides. Connective and bone tissue were further analyzed to identify the amount of newly formed bone. Results. The graft 1 group had a greater formation of vital mineralized tissue when compared to the graft 2 group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009=\u20090.01). For nonvital mineralized tissue and amount of connective tissue, there was no statistical difference (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009=\u20090.21 and <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009=\u20090.09, respectively). The medullary spaces were larger in the graft 2 group. The group treated with graft 1 presented a higher percentage of osteoclasts and viable osteocytes compared to the graft 2 group (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009=\u20090.014 and <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                     <\/i:math>\n                  <\/jats:inline-formula>\u2009=\u20090.027, respectively). Conclusion. Every day, new alternative biomaterials are offered as an option in oral rehabilitation. In this study, both treatments induced bone neoformation after 9 months; however, the group treated with Bio-Oss\u00ae showed a higher percentage of vital mineralized bone tissue.<\/jats:p>","DOI":"10.1155\/2022\/4577148","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T23:05:28Z","timestamp":1654211128000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["A Comparative Histomorphometric Analysis of Two Biomaterials for Maxillary Sinus Augmentation: A Randomized Clinical, Crossover, and Split-Mouth Study"],"prefix":"10.1155","volume":"2022","author":[{"given":"Carlos Ricardo de Queiroz","family":"Martiniano","sequence":"first","affiliation":[{"name":"S\u00e3o Leopoldo Mandic Institute and Research Center, S\u00e3o Paulo, Brazil"},{"name":"Dentistry and Nursing School, Federal University of Ceara, Fortaleza, Ceara, Brazil"},{"name":"Ceara Academy of Dentistry, Fortaleza, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-3089","authenticated-orcid":true,"given":"L\u00eddia Audrey Rocha","family":"Valadas","sequence":"additional","affiliation":[{"name":"Department of Community and Preventive Dentistry, University of Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Ronildo","family":"Lins do Carmo Filho","sequence":"additional","affiliation":[{"name":"Dentistry and Nursing School, Federal University of Ceara, Fortaleza, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5090-6877","authenticated-orcid":true,"given":"Ana Paula Negreiros Nunes","family":"Alves","sequence":"additional","affiliation":[{"name":"Dentistry and Nursing School, Federal University of Ceara, Fortaleza, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9681-1761","authenticated-orcid":true,"given":"Mara Assef","family":"Leit\u00e3o Lotif","sequence":"additional","affiliation":[{"name":"Dentistry and Nursing School, Federal University of Ceara, Fortaleza, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-0299","authenticated-orcid":true,"given":"Bruno Salles","family":"Sotto-Maior","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-2484","authenticated-orcid":true,"given":"Thereza Cristina Farias Botelho","family":"Dantas","sequence":"additional","affiliation":[{"name":"Paulo Pican\u00e7o College of Dentistry, Fortaleza, Brazil"},{"name":"Unichristus, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5913-0713","authenticated-orcid":true,"given":"Luciane Lacerda Franco Rocha","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"S\u00e3o Leopoldo Mandic Institute and Research Center, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-5646","authenticated-orcid":true,"given":"Carlos Eduardo","family":"Francischone","sequence":"additional","affiliation":[{"name":"S\u00e3o Leopoldo Mandic Institute and Research Center, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"47","article-title":"Implantes osseointegrados: evolu\u00e7\u00e3o sucesso","volume":"30","author":"L. 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Martins","year":"2010","journal-title":"Revista Odontol\u00f3gica de Ara\u00e7atuba"},{"key":"8","first-page":"116","article-title":"Histological evaluation of AccellConnexus\u00ae and Bio-Oss\u00ae on quality and rate of bone healing: a single blind experimental study on rabbit\u2019s calvarium","volume":"9","author":"A. Khorsand","year":"2012","journal-title":"Journal of Dentistry"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.11607\/prd.4181"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.11607\/prd.1614"},{"key":"11","first-page":"13","article-title":"Levantamento do seio maxilar com xenoenxerto: resultados cl\u00ednicos e histol\u00f3gicos preliminares","volume":"6","author":"D. B. D. Reis","year":"2011","journal-title":"Innov. Implant. J. Biomater. 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Mummolo","year":"2018","journal-title":"Oral Implantology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01565.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3390\/ma11050714"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4577148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4577148.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4577148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T23:05:45Z","timestamp":1654211145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/4577148\/"}},"subtitle":[],"editor":[{"given":"Hamid","family":"Tebyaniyan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,2]]},"references-count":19,"alternative-id":["4577148","4577148"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4577148","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"type":"electronic","value":"1741-4288"},{"type":"print","value":"1741-427X"}],"subject":[],"published":{"date-parts":[[2022,6,2]]}}}