{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:18:25Z","timestamp":1740140305954,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2008ZX1005"],"award-info":[{"award-number":["2008ZX1005"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,3,23]]},"abstract":"<jats:p>Background and Aim. Coptidis Rhizoma and Evodiae Fructus share the potential to treat nonalcoholic fatty liver disease (NAFLD). Increased fibroblast growth factor (FGF) 21 secreted by hepatocytes is an important self-help behavior in NAFLD. We investigated the effects of GLS (Coptidis Rhizoma-Evodiae Fructus 2\u2009:\u20091) for both their clinical effect and their serum FGF-21 levels in NAFLD patients. Methods. In a 12-week, open-label, exploratory clinical trial, 126 NAFLD patients were randomly divided into the GLS group (lifestyle intervention plus GLS) or the polyene phosphatidylcholine (PPC) group (lifestyle intervention plus PPC). Random numbers generated by DPS software were used in combination with opaque, sealed envelopes for allocation concealment. At baseline as well as at the end of the study, anthropometric parameters, glucose, lipids, hepatic enzymes, and FGF 21 were measured, with hepatic fat accumulation assessed by ultrasound (US) and US-based controlled attenuation parameter (CAP). Results. 119 patients completed the study. Baseline parameters did not significantly differ between the two groups (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Compared with PPC, GLS decreased more significantly in hepatic fat accumulation, body weight index, waist circumference, waist-to-hip ratio, serum glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, alanine transaminase, aspartate transaminase, gamma-glutamyl transferase, and FGF 21 (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The effects of GLS on waist circumference, waist-to-hip ratio, CAP, and gamma-glutamyl transferase (GGT) were positively correlated with serum FGF 21 (r\u2009=\u20090.343, 0.342, 0.315, and 0.374, respectively, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). The GGT and FGF-21 changes were also confirmed by multiple linear regression analysis (B, 0.777; 95% CI: 0.307\u20131.247, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Conclusion. GLS has a significant hepatoprotective effect on NAFLD patients, causing a decrease in FGF-21 secretion in response to the damage itself.<\/jats:p>","DOI":"10.1155\/2022\/4583645","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T21:20:24Z","timestamp":1648070424000},"page":"1-11","source":"Crossref","is-referenced-by-count":4,"title":["An Open-Label Exploratory Clinical Trial Evaluating the Effects of GLS (Coptidis Rhizoma-Evodiae Fructus 2\u2009:\u20091) on Fibroblast Growth Factor 21 in Patients with Nonalcoholic Fatty Liver Disease"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6034-3326","authenticated-orcid":true,"given":"Yang","family":"Zhang","sequence":"first","affiliation":[{"name":"National Integrative Medicine Clinical Base for Infectious Diseases\/Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China"},{"name":"Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-4875","authenticated-orcid":true,"given":"Jian-Xing","family":"Luo","sequence":"additional","affiliation":[{"name":"National Integrative Medicine Clinical Base for Infectious Diseases\/Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-4470","authenticated-orcid":true,"given":"Yan-Ge","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spleen, Stomach, Liver and Gallbladder, Xin Mi Hospital of Traditional Chinese Medicine, Xinmi 452370, Henan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-7401","authenticated-orcid":true,"given":"Hong-Fang","family":"Fu","sequence":"additional","affiliation":[{"name":"Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4054-0389","authenticated-orcid":true,"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7639-788X","authenticated-orcid":true,"given":"Xiao-Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"National Integrative Medicine Clinical Base for Infectious Diseases\/Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"issue":"1","key":"3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cld.2017.08.007","article-title":"Pathophysiology of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"22","author":"V. Manne","year":"2017","journal-title":"Clinics in Liver Disease"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jhep.2017.05.016","article-title":"Treatment of NAFLD with diet, physical activity and exercise","volume":"22","author":"M. Romero-G\u00f3mez","year":"2017","journal-title":"Journal of Hepatology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.05.011"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.02.049"},{"issue":"4","key":"7","first-page":"582","article-title":"Advance in modern studies on compatibility of coptidis rhizoma and Evodiae fructus","volume":"40","author":"C. Qiu","year":"2015","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2019.1577466"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/567045"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(98)00018-x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-17353"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.9"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02338.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.018"},{"issue":"3","key":"15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jhep.2012.10.029","article-title":"High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China","volume":"58","author":"H. Li","year":"2012","journal-title":"Journal of Hepatology"},{"issue":"3","key":"16","first-page":"163","article-title":"Guidelines for management of nonalcoholic fatty liver disease: an updated and revised edition","volume":"18","author":"F. Jian-gao","year":"2010","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"17","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"J. Cohen","year":"1988","edition":"Second"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7260369"},{"issue":"3","key":"19","first-page":"375","article-title":"Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease: a multicenter clinical trial","volume":"3","author":"J. G. Fan","year":"2004","journal-title":"Hepatobiliary and Pancreatic Diseases International"},{"issue":"10","key":"20","first-page":"748","article-title":"Expert recommendations on standardized diagnosis and treatment for fatty liver disease in China (2019 revised edition)","volume":"27","author":"Committee of Hepatology","year":"2019","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200005000-00006"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/s0399-8320(08)73994-0"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2012.05.2543"},{"issue":"2","key":"24","first-page":"226","article-title":"Proportion of Coptidis rhizoma and Evodiae fructus in the compound preparation: its effect in inducing apoptosis of SGC-7901 cells","volume":"31","author":"Q. X. Peng","year":"2011","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.10.010"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020214"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/nature25010"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701600104"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.176"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1168"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.11.009"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1250"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.153994"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.054"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0193"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.11.009"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy358"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133496"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17966"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.10.010"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02781.x"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4583645.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4583645.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4583645.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T21:20:37Z","timestamp":1648070437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/4583645\/"}},"subtitle":[],"editor":[{"given":"Keiichiro","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":41,"alternative-id":["4583645","4583645"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4583645","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"type":"electronic","value":"1741-4288"},{"type":"print","value":"1741-427X"}],"subject":[],"published":{"date-parts":[[2022,3,23]]}}}