{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:49:10Z","timestamp":1747190950478,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Neurological Medicine"],"published-print":{"date-parts":[[2022,4,11]]},"abstract":"<jats:p>Introduction. Several reports have described the use of amantadine for managing symptoms in Marchiafava\u2013Bignami disease (MBD); however, amantadine\u2019s role for the treatment of MBD symptoms is unclear. Here, we describe 2 patients with MBD who were treated with amantadine and hypothesize a potential mechanism responsible for clinical benefit. Case 1. A 38-year-old woman with excessive wine drinking presented with agitation, impaired speech, and a minimally conscious state. MRI revealed lesions in the splenium and genu. After being diagnosed with MBD, she was treated with intravenous thiamine, multivitamins, and 100\u2009mg of amantadine twice a day for 2 weeks. She recovered to near baseline after 3 weeks. Case 2. A 54-year-old woman with years of heavy alcohol use presented with sudden bradyphrenia, acalculia, disinhibited behavior, weakness, and urinary incontinence. MRI revealed a large anterior callosal lesion. Two years after initial recovery from MBD, she noted that consuming \u201cenergy drinks\u201d resulted in a transient, near-complete resolution of her residual behavioral, fatigue, and language symptoms. 100\u2009mg of amantadine twice a day was trialled. After noted improvement, a further escalation to 200\u2009mgs 3 times a day resulted in significant improvement in language and behavioral symptoms. Conclusion. Amantadine in addition to vitamins may be beneficial in the treatment of MBD. It is possible that the dopaminergic effect of amantadine leads to improved recovery and function in dopamine-mediated pathways, including mesocortical and mesolimbic pathways during initial recovery, as well as improved speech, behavior, and fatigue in the following months. The role of amantadine in the treatment of MBD warrants further study.<\/jats:p>","DOI":"10.1155\/2022\/4585206","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T19:35:09Z","timestamp":1649705709000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Amantadine as a Potential Treatment for Marchiafava\u2013Bignami Disease: Case Reports and a Possible Mechanism"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9841-8445","authenticated-orcid":true,"given":"Leenil","family":"Noel","sequence":"first","affiliation":[{"name":"University of South Florida Health Morsani College of Medicine, Tampa, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of South Florida Health Morsani College of Medicine, Tampa, FL, USA"},{"name":"Department of Neurology, James A. Haley Veteran\u2019s Affairs Hospital, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3792-3987","authenticated-orcid":true,"given":"Tigran","family":"Kesayan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, 1301 Medical Center Drive, Nashville, TN, USA"},{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, 1301 Medical Center Drive, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/2324709618784318"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0566-1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000000811"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.07.040"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305979"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/13554794.2018.1444780"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1080\/13554794.2018.1539501"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12572"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2012.00755.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199805000-00026"},{"issue":"2","key":"11","first-page":"156","article-title":"Odwracalna demielinizacja cia\u0142a modzelowatego w przebiegu choroby marchiafavy-bignamiego","volume":"40","author":"J. 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