{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:12:31Z","timestamp":1767168751575,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jinan Municipal Health Commission","award":["2020-3-49"],"award-info":[{"award-number":["2020-3-49"]}]},{"name":"Jinan Municipal Health Commission","award":["SDDX202003"],"award-info":[{"award-number":["SDDX202003"]}]},{"name":"The Open Foundation of Shandong Province Key Laboratory of Oral Tissue Regeneration","award":["2020-3-49"],"award-info":[{"award-number":["2020-3-49"]}]},{"name":"The Open Foundation of Shandong Province Key Laboratory of Oral Tissue Regeneration","award":["SDDX202003"],"award-info":[{"award-number":["SDDX202003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,9,12]]},"abstract":"<jats:p>\n                    Objective. This study aimed to investigate and analyse the clinical efficacy and safety of periocline-assisted periodontal foundation in the therapy of chronic periodontitis. Methods. From May 2018 to January 2021, 108 patients with chronic periodontitis were treated at our institution and randomly assigned equally to either the control or the experimental group. The plaque index (PLI), sulcus bleeding index (SBI), probing depth (PD), and periodontal attachment level (AI) were evaluated before and after periodontal basic therapy in the control group and periocline as an adjunct in the experimental group. Lactobacillus (LB) and Porphyromonas gingivalis (PG) concentrations in saliva were measured before and after therapy, and adverse responses during treatment were noted. Results. The levels of PLI, SBI, PD, and AI in the two groups were significantly lower in both groups at 1 and 3 months posttreatment compared to baseline; the levels of PLI and SBI were higher, and the levels of PD and AI were lower at 3 months after treatment compared to 1 month after treatment; compared with the control group at 1 month and 3 months after treatment, the levels of PLI, SBI, PD, and AI in the experimental group were lower than those in the control group (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). The LB level was higher and the PG level was lower in both groups compared to baseline at 1 and 3 months posttreatment. The LB level was higher and the PG level was lower at 3 months posttreatment compared to 1 month after treatment. Compared with the control group at 1 month and 3 months after treatment, the LB level was higher, and the PG level was lower in the experimental group (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). No significant adverse effects were observed in either group during the treatment period. Only 1 patient in the experimental group had mild gastrointestinal reactions, mainly nausea, without obvious neurological symptoms or abnormal blood changes, which did not affect the treatment. Conclusion. Periodontal fundamental therapy with perioclines may be a potential treatment for persistent periodontitis. It improves the primary clinical indicators, increases dysbacteriosis control, and has a strong safety profile. It could effectively control the development of clinical symptoms of periodontitis and reduce tissue destruction, with obvious clinical treatment effects. It could be used as the first choice for topical treatment of chronic periodontitis. It is recommended for further study by a wide range of researchers.\n                  <\/jats:p>","DOI":"10.1155\/2022\/4601259","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T16:05:07Z","timestamp":1662998707000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["To Explore and Analyze the Safety and Clinical Efficacy of Periocline-Assisted Periodontal Basic Therapy on Chronic Periodontitis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Shengnan","family":"Zhang","sequence":"first","affiliation":[{"name":"Jinan Stomatological Hospital East Branch, Jinan Stomatological Hospital, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Ye","sequence":"additional","affiliation":[{"name":"Jinan Stomatological Hospital East Branch, Jinan Stomatological Hospital, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Jinan Stomatological Hospital, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongdong","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5354-3277","authenticated-orcid":true,"given":"Junru","family":"Meng","sequence":"additional","affiliation":[{"name":"Hospital Infection Management Office, Jinan Stomatological Hospital, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"3","key":"1","first-page":"377","article-title":"Effects of probiotic lozenges combined with basic periodontal therapy on oral pathogenic bacteria and bad breath symptoms in patients with chronic periodontitis","volume":"35","author":"C. 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Yaohui","year":"2020","journal-title":"Journal of General Stomatology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12838"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00623-9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1742132"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_613_20"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2209\/tdcpublication.2021-0033"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.132197"},{"key":"14","first-page":"293","article-title":"The adjuvant effect of Palio in the periodontal basic treatment of moderate and severe periodontitis","volume":"16","author":"W. Yi","year":"2021","journal-title":"Health Must Read"},{"issue":"5","key":"15","first-page":"530","article-title":"The effect of SPR periodontal therapy on C-reactive protein of gingival crevicular fluid in patients with chronic periodontitis","volume":"27","author":"Z. 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Haiyan","year":"2020","journal-title":"Journal of Practical Stomatology"},{"issue":"4","key":"20","first-page":"549","article-title":"Meta-analysis of the efficacy of probiotics in the treatment of periodontitis","volume":"35","author":"S. Lin","year":"2019","journal-title":"Journal of Practical Stomatology"},{"issue":"14","key":"21","first-page":"20","article-title":"Effectiveness of Periocline and Vitapex paste root canal filling in the treatment of combined periodontal and endodontic lesions","volume":"16","author":"F. Gao","year":"2021","journal-title":"China Practical Medicine"},{"issue":"22","key":"22","first-page":"70","article-title":"Observation on the effect of ornidazole carboxymethyl chitosan combined with hyaluronic acid assisted periodontal basic therapy on senile chronic periodontitis","volume":"24","author":"Z. Hongwei","year":"2020","journal-title":"Journal of Practical Clinical Medicine"},{"issue":"6","key":"23","first-page":"949","article-title":"Analysis of the efficacy of probiotics combined with periodontal basic therapy on chronic periodontitis","volume":"36","author":"X. Yue","year":"2020","journal-title":"Journal of Practical Stomatology"},{"issue":"3","key":"24","first-page":"521","article-title":"Clinical and microbial evaluation of photodynamic therapy for adjuvant treatment of chronic periodontitis","volume":"36","author":"B. Longxia","year":"2020","journal-title":"Journal of Practical Stomatology"},{"issue":"3","key":"25","first-page":"157","article-title":"Controlled in vitro bacterial inhibition of periodontal retardants based on soluble collagen","volume":"19","author":"Y. Ma","year":"2021","journal-title":"Chinese Journal of Geriatric Dentistry"}],"updated-by":[{"DOI":"10.1155\/2023\/9823410","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"record-id":"47252"},{"DOI":"10.1155\/2023\/9823410","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000}}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/4601259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/4601259.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/4601259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T16:05:28Z","timestamp":1662998728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/4601259\/"}},"subtitle":[],"editor":[{"given":"Xiaotong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,12]]},"references-count":25,"alternative-id":["4601259","4601259"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4601259","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,12]]}}}