{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:40:21Z","timestamp":1781541621712,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Three-Year Action Plan of Shanghai Traditional Chinese Medicine","award":["2018\u20132020FWTX-1101"],"award-info":[{"award-number":["2018\u20132020FWTX-1101"]}]},{"name":"Three-Year Action Plan of Shanghai Traditional Chinese Medicine","award":["19401971900"],"award-info":[{"award-number":["19401971900"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2018\u20132020FWTX-1101"],"award-info":[{"award-number":["2018\u20132020FWTX-1101"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19401971900"],"award-info":[{"award-number":["19401971900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,9,21]]},"abstract":"<jats:p>Objective. This study aimed to evaluate the effectiveness and safety of Fuzheng Xiaoji granule in patients with stage IIIC colorectal cancer. Methods. A total of 150 patients with stage IIIC colorectal cancer treated in Shanghai Ruijin Hospital from January 2019 to January 2022 were selected. They were divided into treatment and control groups according to a 2\u2009:\u20091 random number table. There were 100 cases in the treatment group and 50 cases in the control group. The treatment group was administered Fuzheng Xiaoji (FZXJ) granule, and the control group was administered the placebo orally. The primary endpoint was disease-free survival (DFS). In addition, after 6 months, the changes in Traditional Chinese Medicine (TCM) symptom score (fatigue, emotional depression, chest tightness, insomnia, anorexia, abdominal distension, abdominal pain, soreness and weakness in the waist and legs, chills, and dysphoria in the chest, palm, and soles) were compared. Results. The DFS was 34.37\u2009\u00b1\u20092.91 months in the control group and 37.0\u2009\u00b1\u20091.08 months in the treatment group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Compared with the control group, the treatment group showed less fatigue, abdominal distension, and soreness and weakness in the waist and legs (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), significantly. The scores of emotional depression and anorexia decreased obviously, with a significant difference between the control and treatment groups (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.01<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). There were no significant differences between the control and treatment groups in the incidence of chest tightness, insomnia, abdominal pain, chills, and dysphoria in the chest, palm, and soles (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>&gt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Conclusion. Fuzheng Xiaoji granule can improve patients\u2019 symptoms and prolong the DFS.<\/jats:p>","DOI":"10.1155\/2022\/4618342","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T23:20:09Z","timestamp":1663802409000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Observation of Fuzheng Xiaoji Granule in the Treatment of Stage IIIC Colorectal Cancer"],"prefix":"10.1155","volume":"2022","author":[{"given":"Lingling","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoheng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9445-7938","authenticated-orcid":true,"given":"Yuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-9264","authenticated-orcid":true,"given":"Lan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000002108"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh275"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200210000-00003"},{"issue":"8","key":"5","first-page":"561","article-title":"Some hot issues in surgical treatment of colorectal cancer","volume":"14","author":"C. Vanderson","year":"2007","journal-title":"Chinese Journal of Cancer Prevention and Treatment"},{"issue":"01","key":"6","first-page":"21","article-title":"Analysis on the law of traditional Chinese medicine in reducing recurrence and metastasis after radical resection of stage II and III colorectal cancer","volume":"16","author":"Y. Y. Du Xin","year":"2014","journal-title":"World science and technology: Modernization of Traditional Chinese Medicine"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1619809"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2174\/1574892815666200717141205"},{"issue":"1","key":"9","first-page":"11","article-title":"Survival analysis of Fuzhong Xiaoji staging therapy in the treatment of rectal cancer","volume":"20","author":"L. Zheng","year":"2018","journal-title":"Journal of Liaoning University of traditional Chinese medicine"},{"key":"10","first-page":"47","article-title":"Clinical guiding significance of treatise on febrile and miscellaneous diseases in treating tumors","volume":"12","author":"Z. Shenxiaoheng","year":"2007","journal-title":"Journal of Shanghai University of Traditional Chinese Medicine"},{"issue":"11","key":"11","first-page":"43","article-title":"Clinical observation on the effect of Fuzhong Xiaoji granule on immune function of postoperative chemotherapy patients with gastric cancer","volume":"34","author":"Z. W. Ying Haifeng","year":"2014","journal-title":"Journal of Hunan University of Traditional Chinese Medicine"},{"key":"12","volume-title":"Effect of Traditional Chinese Medicine Treatment Scheme of Fuzhong Xiaoji on the Survival of Patients with Colon Cancer in: National Annual Conference Of Traditional Chinese Medicine Oncology","author":"S. X. Zhu Weirong","year":"2013"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(00)02034-1"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2000.18.16.2938"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq632"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.33.5091"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1080\/26895293.2021.1963325"},{"issue":"6","key":"18","first-page":"689","article-title":"Application of integrated traditional Chinese and Western medicine symptom management and psychosomatic medicine model in the rehabilitation of colorectal cancer","volume":"28","author":"L. Y. Sun","year":"2021","journal-title":"Chinese Cancer Clinic and Rehabilitation"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4618342.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4618342.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4618342.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T23:20:30Z","timestamp":1663802430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/4618342\/"}},"subtitle":[],"editor":[{"given":"Qing","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,21]]},"references-count":18,"alternative-id":["4618342","4618342"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4618342","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,21]]}}}