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Mutations in the genetic coding and the variations in the spike proteins are critical for the virus\u2019s mechanism of facilitating fusion with the human host, making the disease more severe. Recent research indicates that comorbidities including diabetes, hypertension, renal disease, heart failure, and atherosclerosis play a significant role in the severity and high mortality rates of (COVID-19), suggesting that perhaps the metabolic syndrome and its components are associated with COVID-19 morbidity. Primarily, angiotensin-converting enzyme 2 (ACE2) receptor is identified as the entrance receptor of SARS-CoV-2. Increased ACE2 expression, endothelial dysfunction plays a vital role in the progression and severity of complications developed due to COVID-19. In this review, we will discuss the association and management of cardiorenal disease and COVID-19.<\/jats:p>","DOI":"10.1155\/2022\/4640788","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T10:35:20Z","timestamp":1647599720000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Cardiorenal Disease in COVID-19 Patients"],"prefix":"10.1177","volume":"2022","author":[{"given":"Muhtasham","family":"Sifaat","sequence":"first","affiliation":[{"name":"DeBusk College of Osteopathic MedicineLincoln Memorial University9737 Cogdill RdKnoxvilleTN 37932USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinak","family":"Patel","sequence":"additional","affiliation":[{"name":"DeBusk College of Osteopathic MedicineLincoln Memorial University9737 Cogdill RdKnoxvilleTN 37932USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razan","family":"Sheikh","sequence":"additional","affiliation":[{"name":"DeBusk College of Osteopathic MedicineLincoln Memorial University9737 Cogdill RdKnoxvilleTN 37932USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawood","family":"Ghaffar","sequence":"additional","affiliation":[{"name":"DeBusk College of Osteopathic MedicineLincoln Memorial University9737 Cogdill RdKnoxvilleTN 37932USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitesh","family":"Vaishnav","sequence":"additional","affiliation":[{"name":"DeBusk College of Osteopathic MedicineLincoln Memorial University9737 Cogdill RdKnoxvilleTN 37932USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila","family":"Nahar","sequence":"additional","affiliation":[{"name":"Department of MedicineSchool of Medicine\/John D. 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