{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:38:13Z","timestamp":1770961093397,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["990823"],"award-info":[{"award-number":["990823"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,3,29]]},"abstract":"<jats:p>Purpose. To quantify the longitudinal changes of the optic nerve head (ONH) parameters and peripapillary retinal nerve fiber layer (pRNFL) thickness in patients recovered from coronavirus disease 2019 (COVID-19) using spectral-domain optical coherence tomography (OCT) analysis. Materials and Methods. In an observational longitudinal study, in patients recovered from COVID-19, ONH OCT images were recorded at least two weeks after recovery from the systemic disease as the baseline and after one and three-month follow-up. Ganglion cell complex (GCC) analysis, ONH parameters, and pRNFL thickness changes were measured. Results. A total of 36 eyes from 18 recovered COVID-19 patients including eleven (61.2%) females were studied. The average age was 35.5\u2009\u00b1\u20097.5 years. The pRNFL thickness in the nasal lower sector significantly decreased from 77\u2009\u00b1\u200918\u2009\u03bcm in the first post-COVID-19 month to 74\u2009\u00b1\u200910\u2009\u03bcm in the third month (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.8<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The average, superior, and inferior pRNFL thickness remained unchanged. The average cup volume significantly decreased from 0.27\u2009\u00b1\u20090.15\u2009mm3 at baseline to 0.19\u2009\u00b1\u20090.15\u2009mm3 in the third post-COVID-19 visit (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.028<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). In terms of ONH morphologies including rim, disc and cup to disc area, and the vertical and horizontal ratio, the changes were not significant over the 3-month study period. Focal loss volume and global loss volume values were not changed significantly. Conclusion. Localized defect in the nasal lower sector of pRNFL is observed in 3-month post-recovery from COVID-19. Larger studies with longer follow-ups are required to reveal the exact changes in ONH parameters.<\/jats:p>","DOI":"10.1155\/2022\/4643973","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T22:50:43Z","timestamp":1648594243000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Peripapillary Nerve Fiber Layer Thickness and Optic Nerve Head Parameters in Patients Recovered from COVID-19: A Longitudinal Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-7929","authenticated-orcid":true,"given":"Mojtaba","family":"Abrishami","sequence":"first","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-7352","authenticated-orcid":true,"given":"Kiana","family":"Hassanpour","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-9243","authenticated-orcid":true,"given":"SeyedehMaryam","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Shoeibi","sequence":"additional","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-6415","authenticated-orcid":true,"given":"Mohammad Reza","family":"Ansari-Astaneh","sequence":"additional","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Emamverdian","sequence":"additional","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahareh","family":"Gharib","sequence":"additional","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasibeh","family":"Amini","sequence":"additional","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Abrishami","sequence":"additional","affiliation":[{"name":"Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01764-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04694-x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.120.317015"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09929-7"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.joco.2016.09.009"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1773868"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2020.11.006"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1825751"},{"issue":"1","key":"9","article-title":"Acute macular neuroretinopathy in a patient with acute myeloid leukemia and deceased by COVID-19: a case report","volume":"10","author":"Z. 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Mavi Yildiz","year":"2021","journal-title":"Canadian Journal of Ophthalmology"},{"key":"16","first-page":"562","article-title":"Localized retinal nerve fiber layer defect in patients with COVID-19","volume":"83","author":"K. \u00d6rnek","year":"2021","journal-title":"Arquivos Brasileiros de Oftalmologia"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05965-1"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13473"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30054"},{"key":"20","article-title":"Detection of SARS-CoV-2 genomic and subgenomic RNA in retina and optic nerve of patients with COVID-19","author":"M. 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