{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:49:24Z","timestamp":1781714964243,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shandong Province Medical and Health Science and Technology Development Plan","award":["2019WS403"],"award-info":[{"award-number":["2019WS403"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,5,9]]},"abstract":"<jats:p>Objective. To investigate the clinical effect of minocycline plus zinc oxide eugenol cement in the treatment of acute pulpitis and its effect on the levels of HIF-1\u03b1, Bcl-2, and tumor necrosis factor \u03b1. Methods. A total of 286 patients with acute pulpitis who were treated in our hospital from January 2019 to October 2020 were recruited and assigned (1\u2009:\u20091) via random number table method to receive either minocycline (control group) or minocycline plus zinc oxide eugenol cement (study group). Outcome measures included treatment effect, tooth mobility, tooth percussion pain score, hypoxia-inducible factor (HIF)-1\u03b1 and B-lymphocyte tumor (Bcl)-2 positive rate, and tumor necrosis factor (TNF-\u03b1). Results. Minocycline plus zinc oxide eugenol cement was associated with significantly lower scores of teeth mobility and percussion pain versus minocycline alone (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Minocycline plus zinc oxide eugenol cement resulted in a significantly higher treatment efficacy (97.20%) versus minocycline alone (72.73%) (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Minocycline plus zinc oxide eugenol cement was associated with significantly lower positive rates of HIF-1\u03b1 and Bcl-2 and lower levels of TNF-\u03b1 versus minocycline alone (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). The patients receiving minocycline plus zinc oxide eugenol cement showed significantly lower visual analogue scale (VAS) scores and faster pain relief versus those given minocycline alone (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Conclusion. Minocycline plus zinc oxide eugenol cement offers a viable alternative for acute pulpitis as it mitigates the pain of patients, alleviates inflammatory responses, and lowers the positive rate of HIF-1\u03b1 and Bcl-2, so it is worthy of clinical promotion.<\/jats:p>","DOI":"10.1155\/2022\/4653602","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T22:50:17Z","timestamp":1652136617000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Minocycline plus Zinc Oxide Eugenol Cement Might Be A Promising Alternative for Acute Pulpitis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6949-6444","authenticated-orcid":true,"given":"Hongning","family":"Song","sequence":"first","affiliation":[{"name":"Department of Stomatology, The Second Affiliated Hospital of Shandong First Medical University, Tai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yintao","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The Second Affiliated Hospital of Shandong First Medical University, Tai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaichen","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The Second Affiliated Hospital of Shandong First Medical University, Tai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The Second Affiliated Hospital of Shandong First Medical University, Tai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12392"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.4103\/JCD.JCD_179_19"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004969.pub5"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6747"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2019.06.005"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14642"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.11.009"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020939926"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.08.007"},{"issue":"5","key":"10","first-page":"337","article-title":"Use of non-vital pulp therapies in primary teeth","volume":"42","author":"J. A. Coll","year":"2020","journal-title":"Pediatric Dentistry"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12793"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.07.006"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13215"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13400"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-017-0145-1"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02617-w"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00523-1"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2174\/1574886316666210120090446"},{"key":"19","first-page":"359","article-title":"The anti-inflammatory effect of minocycline on endotoxin-induced uveitis and retinal inflammation in rats","volume":"25","author":"Z. Yuan","year":"2019","journal-title":"Molecular Vision"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.06.019"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3290\/j.jad.a41631"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2018.07.006"}],"updated-by":[{"DOI":"10.1155\/2023\/9850872","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"record-id":"59501"},{"DOI":"10.1155\/2023\/9850872","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000}}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4653602.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4653602.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/4653602.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T22:50:22Z","timestamp":1652136622000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/4653602\/"}},"subtitle":[],"editor":[{"given":"Zhaoqi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,9]]},"references-count":22,"alternative-id":["4653602","4653602"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4653602","relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9850872","asserted-by":"object"}]},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,9]]}}}