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To show the clinical characteristics, identify the magnetic resonance imaging (MRI) and optical coherence tomography (OCT) features, and observe the visual outcome of methanol-induced optic neuropathy. Methods. Clinical data were retrospectively collected from in-patients diagnosed with methanol-induced optic neuropathy in the Neuro-Ophthalmology Department of the Chinese People\u2019s Liberation Army General Hospital from January 2016 to January 2021. Results. Eight patients were included in this study. The exposure time was 6\u201334\u2009h for ingestion, 3-4 months for inhalation, and more than ten years for skin absorption. All patients demonstrated bilateral acute visual impairment. Seven of eight patients had other accompanying systemic symptoms. Seven of eight patients demonstrated optic nerve lesions in MRI, and five presented with a hyperintense T2 signal in a \u201ccentral\u201d type. OCT showed the macular ganglion cell layer and inner plexiform layer (mGCL-IPL) thinning before the peripapillary retinal nerve fiber layer (pRNFL) thinning. The visual improvement was achieved transiently for seven of eight patients after treatment. One patient with a mitochondrial DNA mutation maintained a bilateral no-light perception (NLP) from the onset to the last visit. All patients had poor visual prognoses, with either light perception or NLP. Conclusions. Methanol-induced optic neuropathy is a rare bilateral optic neuropathy with a poor visual outcome. A centrally hyperintense T2 signal of the optic nerve is common in methanol-induced optic neuropathy. The thinning of the mGCL-IPL is more sensitive than that of the pRNFL for early diagnosis. A mitochondrial genetic defect may be a predisposing factor for methanol-induced optic neuropathy.<\/jats:p>","DOI":"10.1155\/2022\/4671671","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T22:35:13Z","timestamp":1668033313000},"page":"1-11","source":"Crossref","is-referenced-by-count":21,"title":["Clinical Characteristics of Methanol-Induced Optic Neuropathy: Correlation between Aetiology and Clinical Findings"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7873-7086","authenticated-orcid":true,"given":"Qiao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Third Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, China"},{"name":"Department of Ophthalmology, Shanghai Aier Eye Hospital, No. 83 Wuzhong Road, Xuhui District, Shanghai 200235, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhao","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihui","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-1377","authenticated-orcid":true,"given":"Quangang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8170-8195","authenticated-orcid":true,"given":"Huanfen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Third Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s12245-020-0264-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-021-03202-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-020-04918-y"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03140-w"},{"key":"5","article-title":"Turkey: police seize bootleg alcohol, nab 10 suspects","author":"H. 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