{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:48:30Z","timestamp":1768268910512,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2022,3,7]]},"abstract":"<jats:p>Brown tumors (BTs) are manifestations of osteitis fibrosa cystica that develops due to increased osteoclast activity secondary to hyperparathyroidism (HPTH). The name comes from its characteristic brown color due to high hemosiderin level and hemorrhage surrounded by osteoclastic giant cells, fibrous tissue, and bone fragments. Presentation can be either unifocal or rarely multifocal. Misdiagnosis of BT compared to malignant giant cell tumor is not uncommon. Early diagnosis and intervention may prevent destructive bone changes. Treatment of BTs due to chronic renal failure should be aimed primarily at its prevention with phosphate binders, vitamin D (analogues), calcimimetics, and prolonged dialysis sessions. Parathyroidectomy can be the option in nonresponsive cases. In this report, we present an unusual case of multiple brown tumors in a 54-year-old female renal transplant patient involving the spine, jaw, and scapula, initially misdiagnosed as giant cell tumor. Five years later, the patient was diagnosed with BT because of the medical history, morphology, and negative p63 staining in combination with secondary\/tertiary hyperparathyroidism. The patient subsequently underwent subtotal parathyroidectomy.<\/jats:p>","DOI":"10.1155\/2022\/4675041","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T23:22:16Z","timestamp":1646695336000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Multiple Focal Brown Tumors (Osteitis Fibrosa Cystica) in a Renal Transplant Recipient"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7724-6442","authenticated-orcid":true,"given":"Thavathurai","family":"Priyanthan","sequence":"first","affiliation":[{"name":"Department of Nephrology, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-0981","authenticated-orcid":true,"given":"Anne Pernille","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-462X","authenticated-orcid":true,"given":"Jonas Asgaard","family":"Bojsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Radiology, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1839-8817","authenticated-orcid":true,"given":"Anne Bruun","family":"Kr\u00f8igaard","sequence":"additional","affiliation":[{"name":"Department of Pathology, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9280-916X","authenticated-orcid":true,"given":"Claus","family":"Bistrup","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-7162","authenticated-orcid":true,"given":"Erik Bo","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"6","key":"1","first-page":"812","article-title":"The first recorded case of osteitis fibrosa cystica","volume":"124","author":"W. Watson Buchanan","year":"1981","journal-title":"Canadian Medical Association Journal"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12298"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4103\/1793-5482.131074"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12002"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4076\/1752-1947-3-7285"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-019-00398-0"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2010.02.022"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.11.009"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000414"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.189"},{"key":"11","first-page":"291","article-title":"Hyperparathyroidism","volume":"16","author":"H. L. 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