{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:28:38Z","timestamp":1768519718402,"version":"3.49.0"},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012528","name":"Kazan Federal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012528","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Nephropathia epidemica (NE) is a zoonotic disease caused by hantaviruses transmitted from rodents, endemic in the Republic of Tatarstan, Russia. The disease presents clinically with mild, moderate, and severe forms, and time\u2010dependent febrile, oliguric, and polyuric stages of the disease are also recognized. The patient\u2019s cytokine responses have been suggested to play a central role in disease pathogenesis; however, little is known about the different patterns of cytokine expression in NE in cohorts of different ages and sexes. Serum samples and clinical records were collected from 139 patients and 57 controls (healthy donors) and were used to analyze 48 analytes with the Bio\u2010Plex multiplex magnetic bead\u2010based antibody detection kits. Principal component analysis of 137 patient and 55 controls (for which there was full data) identified two components that individually accounted for &gt;15% of the total variance in results and together for 38% of the total variance. PC1 represented a proinflammatory TH17\/TH2 cell antiviral cytokine profile and PC2 a more antiviral cytokine profile with patients tending to display one or the other of these. Severity of disease and stage of illness did not show any correlation with PC1 profiles; however, significant differences were seen in patients with high PC1 profiles vs. lower for a number of individual clinical parameters: High PC1 patients showed a reduced number of febrile days, but higher maximum urine output, higher creatinine levels, and lower platelet levels. Overall, the results of this study point towards a stronger proinflammatory profile occurring in younger NE patients, this being associated with markers of acute kidney injury and low levels of high\u2010density cholesterol. This is consistent with previous work indicating that the pathology of NE is immune driven, with an inflammatory immune response being associated with disease and that this immune response is more extreme in younger patients.<\/jats:p>","DOI":"10.1155\/2022\/4685288","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T18:10:47Z","timestamp":1641924647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica"],"prefix":"10.1155","volume":"2022","author":[{"given":"Venera","family":"Shakirova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilseyar","family":"Khaertynova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Markelova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Tarlinton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Behnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-3099","authenticated-orcid":false,"given":"Ekaterina","family":"Martynova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Garanina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Rizvanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-570X","authenticated-orcid":false,"given":"Svetlana","family":"Khaiboullina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655400750045204"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365549409008583"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2101.140861"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.6.921"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1008.031069"},{"key":"e_1_2_9_6_2","first-page":"433","article-title":"Thrombotic thrombocytopenic purpura and hemorrhagic fever with renal syndrome: possible dilemma in differential diagnosis","volume":"57","author":"Radoni\u0107 R.","year":"2003","journal-title":"Acta medica Croatica: casopis Hravatske akademije medicinskih znanosti"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/315522"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.4.868"},{"key":"e_1_2_9_9_2","first-page":"673","article-title":"Localization and changes of hemorrhagic fever with renal syndrome virus in lymphocyte subpopulation","volume":"104","author":"Tang Y.-M.","year":"1991","journal-title":"Chinese Medical Journal"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1977.03280090038018"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2406.172160"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655400750045204"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.4.736"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03994.x"},{"key":"e_1_2_9_15_2","first-page":"26","article-title":"The pathogenetic therapy of patients with a severe form of hemorrhagic fever and acute kidney failure","volume":"69","author":"Germash E.","year":"1997","journal-title":"Terapevticheskii arkhiv"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268815001454"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00970"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.24.11966-11971.2000"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.0007"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.14.88"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2176-x"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000172"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00035-08"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24752"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00567"},{"key":"e_1_2_9_26_2","doi-asserted-by":"crossref","unstructured":"VapalahtiO. 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