{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:13:53Z","timestamp":1781014433114,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Samsung Medical Center","award":["SMX1210841"],"award-info":[{"award-number":["SMX1210841"]}]},{"name":"Samsung Medical Center","award":["BT200044"],"award-info":[{"award-number":["BT200044"]}]},{"name":"Samsung Medical Center","award":["2021R1F1A1064060"],"award-info":[{"award-number":["2021R1F1A1064060"]}]},{"name":"Samsung Medical Center","award":["2018R1D1A1B07046902"],"award-info":[{"award-number":["2018R1D1A1B07046902"]}]},{"name":"Samsung Medical Center","award":["HI14C3484"],"award-info":[{"award-number":["HI14C3484"]}]},{"name":"Seoul R&BD Program","award":["SMX1210841"],"award-info":[{"award-number":["SMX1210841"]}]},{"name":"Seoul R&BD Program","award":["BT200044"],"award-info":[{"award-number":["BT200044"]}]},{"name":"Seoul R&BD Program","award":["2021R1F1A1064060"],"award-info":[{"award-number":["2021R1F1A1064060"]}]},{"name":"Seoul R&BD Program","award":["2018R1D1A1B07046902"],"award-info":[{"award-number":["2018R1D1A1B07046902"]}]},{"name":"Seoul R&BD Program","award":["HI14C3484"],"award-info":[{"award-number":["HI14C3484"]}]},{"name":"Korean government","award":["SMX1210841"],"award-info":[{"award-number":["SMX1210841"]}]},{"name":"Korean government","award":["BT200044"],"award-info":[{"award-number":["BT200044"]}]},{"name":"Korean government","award":["2021R1F1A1064060"],"award-info":[{"award-number":["2021R1F1A1064060"]}]},{"name":"Korean government","award":["2018R1D1A1B07046902"],"award-info":[{"award-number":["2018R1D1A1B07046902"]}]},{"name":"Korean government","award":["HI14C3484"],"award-info":[{"award-number":["HI14C3484"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["SMX1210841"],"award-info":[{"award-number":["SMX1210841"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["BT200044"],"award-info":[{"award-number":["BT200044"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1F1A1064060"],"award-info":[{"award-number":["2021R1F1A1064060"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1D1A1B07046902"],"award-info":[{"award-number":["2018R1D1A1B07046902"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["HI14C3484"],"award-info":[{"award-number":["HI14C3484"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["SMX1210841"],"award-info":[{"award-number":["SMX1210841"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["BT200044"],"award-info":[{"award-number":["BT200044"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["2021R1F1A1064060"],"award-info":[{"award-number":["2021R1F1A1064060"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["2018R1D1A1B07046902"],"award-info":[{"award-number":["2018R1D1A1B07046902"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C3484"],"award-info":[{"award-number":["HI14C3484"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["SMX1210841"],"award-info":[{"award-number":["SMX1210841"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["BT200044"],"award-info":[{"award-number":["BT200044"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["2021R1F1A1064060"],"award-info":[{"award-number":["2021R1F1A1064060"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["2018R1D1A1B07046902"],"award-info":[{"award-number":["2018R1D1A1B07046902"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI14C3484"],"award-info":[{"award-number":["HI14C3484"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Health Technology R&D Project","award":["SMX1210841"],"award-info":[{"award-number":["SMX1210841"]}]},{"name":"Korea Health Technology R&D Project","award":["BT200044"],"award-info":[{"award-number":["BT200044"]}]},{"name":"Korea Health Technology R&D Project","award":["2021R1F1A1064060"],"award-info":[{"award-number":["2021R1F1A1064060"]}]},{"name":"Korea Health Technology R&D Project","award":["2018R1D1A1B07046902"],"award-info":[{"award-number":["2018R1D1A1B07046902"]}]},{"name":"Korea Health Technology R&D Project","award":["HI14C3484"],"award-info":[{"award-number":["HI14C3484"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2022,4,11]]},"abstract":"<jats:p>Mesenchymal stem cells (MSCs) are effective therapeutic agents that contribute to tissue repair and regeneration by secreting various factors. However, donor-dependent variations in MSC proliferation and therapeutic potentials result in variable production yields and clinical outcomes, thereby impeding MSC-based therapies. Hence, selection of MSCs with high proliferation and therapeutic potentials would be important for effective clinical application of MSCs. This study is aimed at identifying the upregulated genes in human Wharton\u2019s jelly-derived MSCs (WJ-MSCs) with high proliferation potential using mRNA sequencing. Aurora kinase A (AURKA) and dedicator of cytokinesis 2 (DOCK2) were selected as the upregulated genes, and their effects on proliferation, migration, and colony formation of the WJ-MSCs were verified using small interfering RNA (siRNA) techniques. mRNA expression levels of both the genes were positively correlated with the proliferation capacity of WJ-MSCs. Moreover, AURKA from human WJ-MSCs regulated the antiapoptotic effect of skeletal muscle cells by upregulating the chemokine (C motif) ligand (XCL1); this was further confirmed in the mdx mouse model. Taken together, the results indicated that AURKA and DOCK2 can be used as potential biomarkers for proliferation and migration of human WJ-MSCs. In particular, human WJ-MSCs with high expression of AURKA might have therapeutic efficacy against muscle diseases, such as Duchenne muscular dystrophy (DMD).<\/jats:p>","DOI":"10.1155\/2022\/4711499","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:50:37Z","timestamp":1649724637000},"page":"1-15","source":"Crossref","is-referenced-by-count":4,"title":["Wharton\u2019s Jelly-Derived Mesenchymal Stem Cells with High Aurora Kinase A Expression Show Improved Proliferation, Migration, and Therapeutic Potential"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-4176","authenticated-orcid":true,"given":"Sun Jeong","family":"Kim","sequence":"first","affiliation":[{"name":"Stem Cell Institute, ENCell Co. Ltd, Seoul 06072, Republic of Korea"},{"name":"Cell and Gene Therapy Institute, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-6426","authenticated-orcid":true,"given":"Sang Eon","family":"Park","sequence":"additional","affiliation":[{"name":"Stem Cell Institute, ENCell Co. Ltd, Seoul 06072, Republic of Korea"},{"name":"Cell and Gene Therapy Institute, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-6530","authenticated-orcid":true,"given":"Jang Bin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Stem Cell Institute, ENCell Co. Ltd, Seoul 06072, Republic of Korea"},{"name":"Cell and Gene Therapy Institute, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-1696","authenticated-orcid":true,"given":"Shin Ji","family":"Oh","sequence":"additional","affiliation":[{"name":"Stem Cell Institute, ENCell Co. Ltd, Seoul 06072, Republic of Korea"},{"name":"Cell and Gene Therapy Institute, Samsung Medical Center, Seoul 06351, Republic of Korea"},{"name":"Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-0419","authenticated-orcid":true,"given":"Alee","family":"Choi","sequence":"additional","affiliation":[{"name":"Stem Cell Institute, ENCell Co. Ltd, Seoul 06072, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-2884","authenticated-orcid":true,"given":"Yun Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Stem Cell Institute, ENCell Co. Ltd, Seoul 06072, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-4789","authenticated-orcid":true,"given":"Suk-joo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-0048","authenticated-orcid":true,"given":"Soo-young","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-1837","authenticated-orcid":true,"given":"Gyu Ha","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"},{"name":"The Office of R&D Strategy & Planning, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-9968","authenticated-orcid":true,"given":"Hong Bae","family":"Jeon","sequence":"additional","affiliation":[{"name":"Stem Cell Institute, ENCell Co. Ltd, Seoul 06072, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-5510","authenticated-orcid":true,"given":"Jong Wook","family":"Chang","sequence":"additional","affiliation":[{"name":"Stem Cell Institute, ENCell Co. Ltd, Seoul 06072, Republic of Korea"},{"name":"Cell and Gene Therapy Institute, Samsung Medical Center, Seoul 06351, Republic of Korea"},{"name":"Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155161"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1021"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X689622"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176269"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0799-4"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.125"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174312"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140611692"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20402"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1159\/000369969"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00258"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"13","volume-title":"R: A language and environment for statistical computing","author":"RDC Team","year":"2016"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3727\/096368917X694705"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1520\/JFS2002414"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/srep12981"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0879-1"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.03.148"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/35090591"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.8.8147"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1242\/dev.137075"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215112001971"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-85"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2011.00757.x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.193662"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0555-9"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.15283\/ijsc18042"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1073-7"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-06-0208"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2008.07.003"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-019-1072-y"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4110"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200602142"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25512"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747157"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020445"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2019.0012"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0676-1"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2016.0331"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.001"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/nri887"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-178939"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.152090"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197013"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00248-3"}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2022\/4711499.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2022\/4711499.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2022\/4711499.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:50:49Z","timestamp":1649724649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/sci\/2022\/4711499\/"}},"subtitle":[],"editor":[{"given":"Jasmin S.","family":"Nurkovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,11]]},"references-count":45,"alternative-id":["4711499","4711499"],"URL":"https:\/\/doi.org\/10.1155\/2022\/4711499","relation":{},"ISSN":["1687-9678","1687-966X"],"issn-type":[{"value":"1687-9678","type":"electronic"},{"value":"1687-966X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,11]]}}}