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Thus, this study aimed at investigating the healing activity of gastric lesion, induced by acetic acid (80%), of the chitosan derivative with acetylacetone (Cac) modified with ethylenediamine (Cacen) or diethylenetriamine (Cacdien). The biological activity was determined based on cytotoxicity, antibacterial activity, and gastroprotective activities. The results showed no significant difference in the cytotoxicity, a better antibacterial activity against S. aureus and E. coli, and a positive result on the healing of gastric lesions of the materials (Cac 18.4%, Cacen 55.2%, and Cacdien 68.1%) compared to pure chitosan (50.7%). Therefore, the results indicate that derivatives of chitosan are promising biomaterials for application in the control of lesions on the gastric mucosa.<\/jats:p>","DOI":"10.1155\/2022\/4743041","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T20:35:10Z","timestamp":1663360510000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Antiulcerogenic and Antibacterial Effects of Chitosan Derivatives on Experimental Gastric Ulcers in Rats"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8594-1613","authenticated-orcid":true,"given":"Leudimar Aires","family":"Pereira","sequence":"first","affiliation":[{"name":"Interdisciplinary Laboratory of Advanced Materials, Postgraduate Program in Materials Science, Federal University of Piau\u00ed, CEP: 64049-550, Teresina, Piau\u00ed, 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