{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T07:02:56Z","timestamp":1760598176107,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Barbara Davis Center for Childhood Diabetes in Denver and at Colorado Heart Imaging Center","award":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"],"award-info":[{"award-number":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"]}]},{"name":"NIH\/NCATS Colorado CTSA","award":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"],"award-info":[{"award-number":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"]}]},{"name":"Adult General Clinical Research Center at the University of Colorado Denver Anschutz Medical Center","award":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"],"award-info":[{"award-number":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"]}]},{"name":"Diabetes Endocrinology Research Center Clinical Investigation Core","award":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"],"award-info":[{"award-number":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"]}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"],"award-info":[{"award-number":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health National Heart, Lung and Blood Institute","award":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"],"award-info":[{"award-number":["UL1TR002535","M01 RR000051","P30 DK57516","7-13-CE-02","7-13-CD-10","7-06-CVD-28","R01 HL113029","R01 HL079611","R01 HL61753"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2022,6,25]]},"abstract":"<jats:p>Type 1 diabetes (T1D) has been associated with increased risks of atherosclerotic cardiovascular disease, and poor glycemic control and oxidative stress play a major role in its pathology. There is a lack of data on the role of dietary antioxidant micronutrients, including vitamins and trace elements, in glycemic control in T1D. The aim of this study is to examine associations of dietary intakes of micronutrients with glycemic status. We report data from a cross-sectional analysis from the coronary artery calcification in type 1 diabetes (CACTI) study (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>1257<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>; T1D: <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>n<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>568<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>; nondiabetic controls: <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>n<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>689<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) collected between the years 2000 and 2002. Participants completed a validated food frequency questionnaire, a physical examination, and biochemical analyses. Linear regression was used to examine the associations of dietary antioxidant micronutrients with HbA1c and estimated insulin sensitivity (eIS) in models adjusted for relevant covariates and stratified by diabetes status. In adults with T1D, we observed higher dietary manganese intake associated with higher eIS in the model adjusted for age, sex, diabetes duration, and total calories. In nondiabetic controls, higher intake of manganese associated with lower HbA1c and higher eIS values that persisted in models adjusted for all relevant covariates. On the other hand, dietary copper revealed a positive association with HbA1c in models adjusted for all covariates, except BMI and plasma lipids. No associations were noted for vitamins C and E and dietary carotenoids in either group. These findings reveal dietary antioxidant micronutrients, especially trace elements such as copper and manganese deserve special attention in glycemic control in adults with T1D as well as in nondiabetic controls.This trial is register with NCT00005754.<\/jats:p>","DOI":"10.1155\/2022\/4747573","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T19:05:17Z","timestamp":1656183917000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Associations of Dietary Antioxidants with Glycated Hemoglobin and Insulin Sensitivity in Adults with and without Type 1 Diabetes"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-9295","authenticated-orcid":true,"given":"Arpita","family":"Basu","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Nutrition Sciences, School of Integrated Health Sciences, University of Nevada Las Vegas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy C.","family":"Alman","sequence":"additional","affiliation":[{"name":"College of Public Health, University of South Florida, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet K.","family":"Snell-Bergeon","sequence":"additional","affiliation":[{"name":"Barbara Davis Center for Childhood Diabetes, University of Colorado, Anschutz Medical Campus, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399816666200511004205"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.16425"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.05.035"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.058"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.01.003"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-S005"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/53.4.1050S"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2003.10719272"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb17085.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1579-5"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2017.04.009"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-012-0473-7"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602047"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0571-x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.600"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27491"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-119"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1900\/rds.2017.14.269"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3272"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1280-4"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3390\/nu13031035"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-015-9834-z"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.02.010"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2021.06.008"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-010-8650-0"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3390\/nu13114044"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.2.305"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1954"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1080\/03630260701727077"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0243"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4674-3"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2020.10.009"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7580707"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1445"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.3109\/10715760903494168"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095008"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12534"},{"issue":"6","key":"38","first-page":"637","article-title":"Dietary reference intakes for the antioxidant nutrients: vitamin C, vitamin E, selenium, and carotenoids","volume":"100","author":"E. 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