{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T17:29:20Z","timestamp":1772040560053,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":199,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Abnormal proliferation of vascular smooth muscle cells (VSMCs) is an important cause of vascular stenosis. The study explored the mechanism of inhibition of vascular stenosis through the molecular mechanism of smooth muscle cell phenotype transformation. <jats:italic>Methods<\/jats:italic>. Coronary heart disease\u2010related genes were screened by bioinformatics, and the target genes of miR\u2010654\u20105p were predicted by dual\u2010luciferase method and immunofluorescence method. miR\u2010654\u20105p mimic stimulation and transfection of TCF21 and MTAP into cells. SonoVue microbubble sonication was used to deliver miR\u2010654\u20105p into cells. Cell proliferation, migration, and invasion were detected by CCK\u20108, wound scratch, and Transwell. HE and IHC staining were performed to study the effect of miR\u2010654\u20105p delivery via SonoVue microbubble ultrasound on vessel stenosis in a model of arterial injury. Gene expression was determined by qRT\u2010PCR and WB. <jats:italic>Results<\/jats:italic>. TCF21 and MTAP were predicted as the target genes of miR\u2010654\u20105p. Cytokines induced smooth muscle cell proliferation, migration, and invasion and promoted miR\u2010654\u20105p downregulation; noticeably, downregulated miR\u2010654\u20105p was positively associated with the cell proliferation and migration. Overexpression of TCF21 promoted proliferation, invasion, and migration, and mimic reversed such effects. miR\u2010654\u20105p overexpression delivered by SonoVue microbubble ultrasound inhibited proliferation, migration, and invasion of cells. Moreover, in arterial injury model, we found that SonoVue microbubble ultrasound transmitted miR\u2010654\u20105p into the arterial wall to inhibit arterial thrombosis and stenosis, while TCF21 was inhibited. <jats:italic>Conclusion<\/jats:italic>. Ultrasound delivery of miR\u2010654\u20105p via SonoVue microbubbles was able to inhibit arterial thrombosis and stenosis by targeting TCF21.<\/jats:p>","DOI":"10.1155\/2022\/4757081","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T23:05:06Z","timestamp":1658271906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["[Retracted] Delivery of miR\u2010654\u20105p via SonoVue Microbubble Ultrasound Inhibits Proliferation, Migration, and Invasion of Vascular Smooth Muscle Cells and Arterial Thrombosis and Stenosis through Targeting TCF21"],"prefix":"10.1155","volume":"2022","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruohan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-4529","authenticated-orcid":false,"given":"Changjie","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.51"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17008"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000478918"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.06.054"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultras.2016.10.014"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.2895"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487318777435"},{"key":"e_1_2_7_8_2","first-page":"255","article-title":"Mechanisms and treatments for renal artery stenosis","volume":"16","author":"Haller S. 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