{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:13:57Z","timestamp":1783628037400,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":97,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Controlling the invasive activity of trophoblastic tissue has not been elucidated. In the accreta placenta, the invasion of placental tissue is directly related to the expression of CRIPTO\u20101 at the maternal\u2010fetal interface. The aim of this study is to evaluate if the expression of the CRIPTO\u20101 is related to different degrees of trophoblast invasion into the tube wall in ampullary pregnancy. <jats:italic>Methods<\/jats:italic>. Prospective study with 21 patients with ampullary tubal pregnancy undergoing salpingectomy. Anatomopathological evaluation determined the degree of invasion of trophoblast tissues into the tubal wall and grouped the samples into invasive degrees I, II, or III. The groups were compared for tissue expression of CRIPTO\u20101 using the Kruskal\u2010Wallis nonparametric test. <jats:italic>p<\/jats:italic> values lower than 0.05 were considered significant. <jats:italic>Results<\/jats:italic>. Quantitative expression of CRIPTO\u20101 differed in each of the three groups of trophoblast invasion in the tubal wall in ampullary pregnancies (<jats:italic>p<\/jats:italic> &lt; 0.001). There is a difference between groups when grade I\u2009+\u2009grade II versus grade III (<jats:italic>p<\/jats:italic> &lt; 0.001) and grade I versus grade II\u2009+\u2009grade III (<jats:italic>p<\/jats:italic> &lt; 0.001). The tissue expression of CRIPTO\u20101 in ectopic trophoblasts showed that deeper invasion of the tubal wall was associated with stronger expression than in shallow invasion (<jats:italic>p<\/jats:italic> &lt; 0.001). <jats:italic>Discussion<\/jats:italic>. In ampullary pregnancies, the depth of penetration of trophoblast tissue in the tubal wall is related to CRIPTO\u20101 tissue expression.<\/jats:p>","DOI":"10.1155\/2022\/4769790","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T21:05:31Z","timestamp":1649451931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["CRIPTO\u20101 Is Immunolocalized in the Syncytiotrophoblast of Ampullary Pregnancies"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-2136","authenticated-orcid":false,"given":"F\u00e1bio Roberto","family":"Cabar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-9757","authenticated-orcid":false,"given":"Pedro 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