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Evidence supported that dyslipidemia in childhood is associated with atherosclerosis in adulthood, and early identification and treatment potentially reduce cardiovascular risk in adulthood, which is the principal cause of morbidity and mortality in developed countries. Dyslipidemias can result from primary lipoprotein metabolism changes due to different genetic causes (primary dyslipidemias) or as a consequence of exogenous factors or other pathologies (secondary dyslipidemias). Therefore, the combined dyslipidemias result from the association of important epigenetic and environmental influences with risk factors for cardiovascular disease. The criterion for lipid metabolism screening at young ages is not widely accepted and possibly follows a universal or directed screening strategy. Additionally, little is known about its long\u2010term effects or possible risk\u2010benefit despite the growing tendency to start pharmacological therapy. Therefore, this study aimed to review the available bibliography on dyslipidemia in pediatric age to present a practical and structured approach to dyslipidemia that focuses on screening, risk stratification for atherosclerotic disease, and therapeutic approach.<\/jats:p>","DOI":"10.1155\/2022\/4782344","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:06:10Z","timestamp":1645470370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Dyslipidemia Diagnosis and Treatment: Risk Stratification in Children and Adolescents"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-7236","authenticated-orcid":false,"given":"Sara","family":"Mosca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-6548","authenticated-orcid":false,"given":"Gra\u00e7a","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8936-1459","authenticated-orcid":false,"given":"Vanessa","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-6840","authenticated-orcid":false,"given":"Joana","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1203-8180","authenticated-orcid":false,"given":"Anabela","family":"Bandeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9247-9391","authenticated-orcid":false,"given":"Esmeralda","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8688-5169","authenticated-orcid":false,"given":"Helena","family":"Mansilha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0807-8120","authenticated-orcid":false,"given":"M\u00f3nica","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6471-4067","authenticated-orcid":false,"given":"Margarida P.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_10_1_2","unstructured":"Sa\u00fade DG de Portugal Programa nacional de sa\u00fade infantil e juvenil 2013."},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0052-6"},{"key":"e_1_2_10_3_2","first-page":"1","volume-title":"Dyslipidemia in Children: Definition, Screening, and Diagnosis","author":"De Ferranti S.","year":"2016"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789x.2004.00133.x"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789x.2009.00674.x"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801581"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.05.060"},{"key":"e_1_2_10_8_2","unstructured":"Instituto nacional de estat\u00edstica Causas de morte 2017 2020."},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1349"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117445"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2009.00056.x"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.137"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199806043382302"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1472"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2015.01.012"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.01.010"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.25.1.4"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2011.222"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.11.1546"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4759"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-49410-3_2"},{"key":"e_1_2_10_22_2","first-page":"4","article-title":"Dislipidemias na Inf\u00e2ncia e na adolesc\u00eancia: um caso de sa\u00fade p\u00fablica? 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