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As a common complication of DM, diabetic foot ulcer (DFU) results in delayed wound healing and is a leading cause of nontraumatic amputation. miR\u2010199a\u20105p, a short noncoding RNA, had abnormal expression in DFU wound tissues. The expression of miR\u2010199a\u20105p was significantly increased in DFU wound tissues, skin tissues of diabetic rats, and high glucose\u2010induced cells. Vascular endothelial growth factor A (VEGFA) and Rho\u2010associated kinase 1 (ROCK1) are directly targets of miR\u2010199a\u20105p. Inhibiting the expression of miR\u2010199a\u20105p alleviated the inhibition of VEGFA and ROCK1, thereby rescued impaired proliferation and migration of HG\u2010induced cells, and restored the normal function of the cells to some extent. 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