{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:46:45Z","timestamp":1791229605118,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":212,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Great plantain (\n                    <jats:italic>Plantago major<\/jats:italic>\n                    L. or\n                    <jats:italic>P.major<\/jats:italic>\n                    ) is a medicinal plant that is available all around the world. The whole plant has several bioactive compounds including terpenoids, flavonoids, phenolic compounds, alkaloids, fatty acids, iridoid glycosides, polysaccharides, and vitamins. Scientific studies have recognized several medical benefits like wound healing, anti\u2010inflammatory, antimicrobial, antiulcerative, and antioxidative agents. The wound\u2010healing capacity of this plant has been investigated under\n                    <jats:italic>in vivo<\/jats:italic>\n                    and ex vivo conditions. In the current study, we aim to compare the therapeutic effect of the\n                    <jats:italic>P.major<\/jats:italic>\n                    extract with 1% sulfadiazine on the healing of second\u2010degree burn wounds.\n                    <jats:italic>Method<\/jats:italic>\n                    . Second\u2010degree burn victims were included in our study. The investigation and control group, respectively, received\n                    <jats:italic>P. major<\/jats:italic>\n                    ointment 10% and silver sulfadiazine ointment 1%. The bacterial culture from the wound site was taken on days 3, 7, 10, 13, and last day of hospitalization. Patients\u2019 subjective complaints were obtained through the visual analog scale (VAS). All patients were treated and evaluated in the hospital.\n                    <jats:italic>Result<\/jats:italic>\n                    . Among the 15 patients, 11 were male, and the mean age was 33.3 years. The average complete healing duration was 11.73\n                    <jats:italic>vs<\/jats:italic>\n                    . 13 days in the\n                    <jats:italic>P. major<\/jats:italic>\n                    and control group, respectively (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.166). On the third day, infection control was similar between the two groups, and on the seventh day, all bacterial cultures were negative. Although there was a significant reduction in pain scores during the recovery time, no significant differences in pain reduction were noted between the two groups (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.849).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . We showed that\n                    <jats:italic>P.major<\/jats:italic>\n                    ointment is a safe and suitable herbal compound in the treatment of second\u2010degree burn wounds that not only has wound\u2010healing properties but also is an analgesic and antimicrobial compound.\n                  <\/jats:p>","DOI":"10.1155\/2022\/4923277","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T15:20:18Z","timestamp":1659367218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Therapeutic Efficacy of Great Plantain (\n                    <i>Plantago major<\/i>\n                    L\n                    <i>.<\/i>\n                    ) in the Treatment of Second\u2010Degree Burn Wounds: A Case\u2010Control 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