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Resveratrol (Res), a natural polyphenol existing in Polygonum cuspidatum, has been widely investigated for its antinociceptive, anti\u2010inflammatory, and neuroprotective properties. Our aim was to explore the ameliorating effects of resveratrol on pain\u2010related behaviors and learning and memory deficits induced by cobra venom\u2010induced trigeminal neuralgia (TN). The TN model of rats was established by injecting cobra venom solution beneath the epineurium of the infraorbital nerve. Resveratrol was intragastrically administered at a dose of 40\u2009mg\/kg twice daily beginning on postoperative day 15. CREB inhibitor 666\u201015 was intraperitoneally administered at a dose of 10\u2009mg\/kg from POD 35\u201042 after morning resveratrol treatment. Mechanical allodynia was measured via von Frey filaments. Rat free movement was videotaped and analyzed. Spatial learning and memory were evaluated via the Morris water maze test. Ultrastructures of the hippocampal DG region and infraorbital nerve were observed by transmission electron microscopy. We found that resveratrol alleviated TN\u2010induced allodynia, ameliorated learning and memory deficits, restored the ultrastructure of hippocampal neurons and synapses, repaired the damaged myelin sheath of the infraorbital nerve, and activated the CREB\/BDNF pathway in the hippocampus of TN rats. CREB inhibitor administration suppressed the resveratrol\u2010rescued abnormal hippocampal ultrastructural changes and aggravated spatial learning and memory impairment by inhibiting CREB\/BDNF pathway activation in the hippocampus. Our findings indicated that resveratrol alleviated pain and improved cognitive deficits, probably by regulating neural ultrastructure remodelling and the CREB\/BDNF pathway.<\/jats:p>","DOI":"10.1155\/2022\/4926678","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T07:40:31Z","timestamp":1669707631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Resveratrol Ameliorates Trigeminal Neuralgia\u2010Induced Cognitive Deficits by Regulating Neural Ultrastructural Remodelling and the CREB\/BDNF Pathway in 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