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However, what we know about the m6A regulators in Ankylosing spondylitis (AS) is still limited. In our study, eight distinct m6A regulators were selected utilizing Differentially Expressed Gene (DEG) analysis of the Gene Expression Omnibus GSE73754 dataset for making comparisons between AS (Ankylosing spondylitis) and non-AS patients. The random forest model and the nomogram model were used to screen the eight candidate m6A regulators and evaluate their prediction accuracy for the occurrence of AS. Furthermore, based on the selected m6A regulators, the AS patients were divided into two subgroups, and we applied principal component analysis algorithms to calculate their m6A score and evaluate the m6A patterns. Our findings revealed that patients in cluster A were linked to activated CD4 T cell immunity and activated CD8 T cell immunity. With its major contributions in the area of immunology, our research in m6A patterns may benefit the future diagnosis and treatment strategies of AS.<\/jats:p>","DOI":"10.1155\/2022\/4942599","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T21:05:33Z","timestamp":1663362333000},"page":"1-23","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of N6-Methyladenosine RNA Methylation Regulators in Diagnosis and Distinct Molecular Subtypes of Ankylosing Spondylitis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1211-8968","authenticated-orcid":true,"given":"Cheng","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China"},{"name":"Department of Orthopedics, Jiangmen Hospital of Traditional Chinese Medicine Affiliated to Jinan University, Jiangmen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6375-7444","authenticated-orcid":true,"given":"Jia-hua","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-0077","authenticated-orcid":true,"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4466-8814","authenticated-orcid":true,"given":"Li-ping","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Jiangmen Hospital of Traditional Chinese Medicine Affiliated to Jinan University, Jiangmen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5336-368X","authenticated-orcid":true,"given":"Guo-dong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4725-4628","authenticated-orcid":true,"given":"Wei-xing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4313-8184","authenticated-orcid":true,"given":"Dong-ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-8229","authenticated-orcid":true,"given":"Wen-de","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-6103","authenticated-orcid":true,"given":"Hao-hua","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-6382","authenticated-orcid":true,"given":"Da-xiang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Jiangmen Hospital of Traditional Chinese Medicine Affiliated to Jinan University, Jiangmen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31591-4"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000475"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.18502\/jovr.v16i3.9440"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/art.40149"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.103"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406182"},{"issue":"11","key":"7","first-page":"780","article-title":"Ankylosing spondylitis: an update","volume":"42","author":"V. 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